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1.
Chem Soc Rev ; 49(8): 2481-2503, 2020 Apr 21.
Artigo em Inglês | MEDLINE | ID: mdl-32176233

RESUMO

Chirality is ubiquitous in nature and plays mysterious and essential roles in maintaining key biological and physiological processes. As biological systems display high selectivity for chiral biomolecules, chiral bio-nanoscience has become a popular research field during the last decade. Homochirality, as an essential attribute of natural compounds (l-amino acids, d-sugars, etc.), inspired the emergence of synthetic chiral nanomaterials, which in turn impacted their biological functions and fates. This review is a comprehensive overview of the interactions between chiral inorganic nanostructures and biosystems. We start with the recent progress in biocompatible chiral nanomaterials and focus on stereospecific biological interactions ranging from enantioselective reactions in applications such as sensing and catalysis to chirality-dependent controllable manipulation of cell behaviours and finally to enantiopure nanoplatforms for improved disease therapy. We also discuss the current challenges and future potential of these chiral nanotechnologies in biomedicine and bioengineering, provide strategies to overcome these barriers and offer a future perspective.


Assuntos
Compostos Inorgânicos/química , Compostos Inorgânicos/metabolismo , Nanoestruturas/química , Animais , Materiais Biocompatíveis/química , Materiais Biocompatíveis/metabolismo , Humanos , Estereoisomerismo
2.
Adv Mater ; 34(31): e2203734, 2022 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-35681250

RESUMO

Alloying is an efficient chemistry to tailor the properties of metal clusters. As a class of promising radiosensitizers, most previously reported metal clusters exhibit unitary function and cannot overcome radioresistance of hypoxic tumors. Here, atomically precise alloy clusters Pt2 M4 (M = Au, Ag, Cu) are synthesized with bright luminescence and adequate biocompatibility, and their composition-dependent enzyme mimicking activity and radiosensitizing effect is explored. Specifically, only the Pt2 Au4 cluster displays catalase-like activity, while the others do not have clusterzyme properties, and its radiosensitizing effect is the highest among all the alloy clusters tested. By taking advantage of the sustainable production of O2 via the decomposition of endogenous H2 O2 , the Pt2 Au4 cluster modulates tumor hypoxia as well as increases the efficacy of radiotherapy. This work thus advances the cluster alloying strategy to produce multifunctional therapeutic agents for improving hypoxic tumor therapy.


Assuntos
Neoplasias , Radiossensibilizantes , Ligas , Humanos , Hipóxia , Neoplasias/radioterapia , Radiossensibilizantes/farmacologia , Hipóxia Tumoral
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