Synthesis, molecular modeling and biological evaluation of PSB as targeted antibiotics.

We described here the design, synthesis, molecular modeling, and biological evaluation of a series of peptide and Schiff bases (PSB) small molecules, inhibitors of Escherichia coli beta-Ketoacyl-acyl carrier protein synthase III (ecKAS III). The initial lead compound was reported by us previously, we continued to carry out structure-activity relationship studies and optimize the lead structure to potent inhibitors in this research. The results demonstrated that both N-(2-(3,5-dichloro-2-hydroxybenzylideneamino)propyl)-2-hydroxybenzamide (1f) and 2-hydroxy-N-(2-(2-hydroxy-5-iodobenzylideneamino)propyl)-4-methylbenzamide (3e) posses good ecKAS III inhibitory activity and well binding affinities by bonding Gly152/Gly209 of ecKAS III and fit into the mouth of the substrate tunnel, and can be as potential antibiotics agent, displaying minimal inhibitory concentration values in the range 0.20-3.13microg/mL and 0.39-3.13microg/mL against various bacteria.

[Clinical study of two fixed prosthetics in dentition defect of Kennedy I and II type].

PURPOSE: To investigate the feasibility and clinical effect of two fixed prosthetic, supported by implant alone or by implant and natural teeth, in dentition defect of Kennedy I or II type. METHODS: Sixty subjects with dentition defect of Kennedy I or II were collected. They were divided into group A and group B, 30 subjects in each group respectively. Group A was restore with PFM crown or bridge, supported by implant or implant combined with natural teeth. Group B was treated by cantilever fixed bridge supported by natural teeth. The treatment outcomes were analyzed with SPSS17.0 software package. RESULTS: With 5 years of follow-up, all subjects in group A and 26/30 subjects in group B had successful restoration. There was significant difference in successful rate between group A and group B(P<0.05). CONCLUSION: Fixed prosthetics supported by implant alone and by both implant and natural teeth, in dentition defect of Kennedy I or II is feasible and its clinical effect is satisfactory. Supported by Research Fund of Science and Technology Commission of Fengxian District, Shanghai Municipality(Grant No.96-3).

[Clinical application of self-regulating exterior bracket for zygomatic fracture].

PURPOSE: To investigate the clinical value of self-regulating exterior bracket for zygomatic fracture. METHODS: Thirty patients with unilateral zygomatic fracture were treated using self-regulating exterior bracket. They all had limitation of mouth opening and facial collapse. 1.5 cm incision was made from the distal upper first molar. After reducting to normal mouth opening and symmetrical face, self-regulating external bracket was used to fix the fracture for 3 weeks. RESULTS: After removing the self-regulating bracket, X-ray showed the fracture healing well. The patients had normal mouth opening. CONCLUSION: The clinical effect of using self-regulating bracket to fix fracture after reduction for unilateral zygomatic fracture is good, it is a simple surgical method.

[Clinical report of early implant-supported mandibular overdenture retained by conical crowns].

PURPOSE: To investigate the feasibility and clinical effectiveness of inchoate implant-supported mandibular overdenture retained by conical crowns. METHODS: In this study, 25 patients with edentulous mandible were included.All patients received 4 to 6 dental implants between the mental foramen and impression taking immediately to make overdenture retained by conical crowns,loading in ten days.All patients were followed up for 1,3,6,12,24 and 36 months, and then once a year.The stability of one implants, the state of peri-implant soft-tissue were recorded, and calculus of peri-implant was cleared. And the state of marginal bone resorption, osseointegration of implants were examined by X-ray films. RESULTS: A total of 103 implants were loaded early, 3 failed.The others had osseointegration,no infection of peri-implant soft-tissue occurred,no implants exhibited peri-implant radiolucencies. The patients were satisfied with the outcomes. CONCLUSIONS: The results of this clinical report suggest that immediate loading of the implants by conical crowns to support overdenture prostheses for edentulous mandible is feasible between the mental foramen. The short-term clinical effectiveness of early loading is good.

[Clinical stability of immediate load of domestic micro-titanium screws for anchorage in orthodontics].

PURPOSE: To investigate the immediate load stability of domestic micro-titanium screws for anchorage in orthodontics. METHODS: Adult orthodontic patients needing the greatest anchorage were included in the study. Domestic micro-titanium screws were used to be orthodontic anchorage, immediate implantation and loading were conducted. RESULTS: A total of 52 implants of domestic micro-titanium anchorage in 20 patients were used. Forty-seven implants were successful in 20 patients,5 failed. The total loading time was 3-8 months. CONCLUSIONS: Domestic micro-titanium implant screws for anchorage can meet the needs of clinical orthodontics. However, immediate loading results in 10.4% failure rate, especially for the implant with a diameter of 1.2mmx7mm. Supported by Science and Technology Development Foundation of Fengxian District, Shanghai Municipality (Grant No. 090602).