RESUMO
Supramolecular polymers have attracted considerable interest due to their intriguing features and functions. The dynamic reversibility of noncovalent interactions endows supramolecular polymers with tunable physicochemical properties, self-healing, and externally stimulated responses. Among them, pillararene-based supramolecular polymers show great potential for biomedical applications due to their fascinating host-guest interactions and easy modification. Herein, we summarize the state of the art of pillararene-based supramolecular polymers for cancer therapy and illustrate its developmental trend and future perspective.
Assuntos
Neoplasias , Polímeros , Humanos , Polímeros/uso terapêutico , Polímeros/química , Neoplasias/tratamento farmacológicoRESUMO
Among the many challenges in medicine, the treatment and cure of cancer remains an outstanding goal given the complexity and diversity of the disease. Nanotheranostics, the integration of therapy and diagnosis in nanoformulations, is the next generation of personalized medicine to meet the challenges in precise cancer diagnosis, rational management and effective therapy, aiming to significantly increase the survival rate and improve the life quality of cancer patients. Different from most conventional platforms with unsatisfactory theranostic capabilities, supramolecular cancer nanotheranostics have unparalleled advantages in early-stage diagnosis and personal therapy, showing promising potential in clinical translations and applications. In this review, we summarize the progress of supramolecular cancer nanotheranostics and provide guidance for designing new targeted supramolecular theranostic agents. Based on extensive state-of-the-art research, our review will provide the existing and new researchers a foundation from which to advance supramolecular cancer nanotheranostics and promote translationally clinical applications.
Assuntos
Antineoplásicos/química , Nanoestruturas/química , Neoplasias/diagnóstico , Neoplasias/terapia , Medicina de Precisão/métodos , Nanomedicina Teranóstica/métodos , Animais , Antineoplásicos/farmacologia , Transporte Biológico , DNA/química , Humanos , Lipossomos/química , Nucleotídeos/química , Compostos Organometálicos/química , Proteínas/químicaRESUMO
A new molecular recognition motif between a water soluble pillar[10]arene (WP10) and 1,10-phenanthrolinium guest (G) in water is established. Mainly driven by the cooperativity of multiple electrostatic interactions, hydrophobic interactions, and π-π stacking interactions between WP10 and G, this host-guest complex exhibits a high association constant in water, which is about 17 times higher than that between WP10 and paraquat (PQ). Furthermore, this size selective host-guest complexation is employed to tune the lower critical solution temperature behavior of a random copolymer with PQ derivative pendants.