Efficacy of antimicrobial agents incorporated in orthodontic bonding systems: a systematic review and meta-analysis.

AIMS: The purpose of this study was to evaluate the efficacy of orthodontic bonding systems containing different antimicrobial agents, as well as the influence of antimicrobial agent incorporation in the bonding properties of these materials. METHODS: Eight databases were searched: PubMed (Medline), Web of Science, Scopus, Lilacs, Ibecs, BBO, Scielo and Google Scholar. Any study that evaluated antimicrobial activity in experimental or commercial orthodontic bonding systems was included. DATA EXTRACTION: Data were tabulated independently and in duplicated by two authors on pre-designed data collection form. DATA SYNTHESIS: The global analysis was carried out using a random-effects model, and pooled-effect estimates were obtained by comparing the standardised mean difference of each antimicrobial orthodontic adhesive with the respective control group. A p-value < .05 was considered as statistically significant. RESULTS: Thirty-two studies were included in the qualitative analysis; of these, 22 studies were included in the meta-analysis. Antimicrobial agents such as silver nanoparticles, benzalkonium chloride, chlorhexidine, triclosan, cetylpyridinium chloride, Galla chinensis extract, acid ursolic, dimethylaminododecyl methacrylate, dimethylaminohexadecyl methacrylate, 2-methacryloyloxyethyl phosphorylcholine, 1,3,5-triacryloylhexahydro-1,3,5-triazine, zinc oxide and titanium oxide have been incorporated into orthodontic bonding systems. The antimicrobial agent incorporation in orthodontic bonding systems showed higher antimicrobial activity than the control group in agar diffusion (overall standardised mean difference: 3.71; 95% CI 2.98 to 4.43) and optical density tests (0.41; 95% CI -0.05 to 0.86) (p < .05). However, for biofilm, the materials did not present antimicrobial activity (6.78; 95% CI 4.78 to 8.77). Regarding bond strength, the global analysis showed antimicrobial orthodontic bonding systems were statistically similar to the control. CONCLUSIONS: Although there is evidence of antibacterial activity from in vitro studies, clinical and long-term studies are still necessary to confirm the effectiveness of antibacterial orthodontic bonding systems in preventing caries disease.

A comparison of the mandibular index on panoramic and cross-sectional images from CBCT exams from osteoporosis risk group.

UNLABELLED: Osteoporosis is a degenerative disease that primarily affects postmenopausal women. Based on panoramic radiographs, several assessment methods have been proposed for the diagnosis and evaluation of bone changes and as a predictor of osteoporosis for example the mandibular index. INTRODUCTION: The purpose of this study is to compare the assessment of mandibular indices on panoramic and cross-sectional images. METHODS: Forty-four cone beam computed tomography (CBCT) images from postmenopausal female subjects aged more than 45 years without systemic changes were selected for this study. From those images, cross-sectional and panoramic reconstruction images were assembled into a template for evaluation. The evaluation was conducted by observing the panoramic images and parasagittal sections. The appearance of the inferior cortex of the mandible was classified according to the mandibular index: C1, the endosteal margin of the cortex was even and sharp; C2, the endosteal margin presented semilunar defects or appeared to form endosteal cortical residues; or C3, the cortical layer formed heavy endosteal cortical residues and was clearly porous. RESULTS: Based on Wilcoxon statistical test (p > 0.01), the data showed no statistically significant difference between the exams. CONCLUSION: The mandibular index assigned in tomographic images is comparable to that obtained in panoramic images, indicating a valid use of the index in CBCT images, which can lead to the identification of patients with bone mass loss and a premature referral to further exams and treatment.

GAND classification and volumetric assessment of unilateral cleft lip and palate malformations using cone beam computed tomography.

The aim of this study was to propose a classification for unilateral cleft lip and palate (UCLP) malformations based on cone beam computed tomography (CBCT) images, as well as to estimate the amount of bone necessary for grafting, and to evaluate the relationship of this volume with scores obtained using the classification. CBCT images of 33 subjects with UCLP were evaluated according to gap, arch, nasal, and dental parameters (GAND classification). Additionally, these defects were segmented and the amount of graft needed for alveolar bone grafting was estimated. The reproducibility of GAND classification was analyzed by weighted kappa test. The association of volume assessment with the classification (gap and nasal parameters) was verified using analysis of variance, while the intra-observer agreement was analyzed using the intra-class correlation coefficient. The intra-observer reproducibility of the classification ranged from 0.29 to 0.92 and the inter-observer agreement ranged from 0.29 to 0.91. There were no statistically significant values when evaluating the association of the volume with the classification (P>0.05). The GAND classification is a novel system that allows the quick estimation of the extent and complexity of the cleft. It is not possible to estimate the amount of bone needed for alveolar bone grafting based on the classification; individualized surgical planning should be done for each patient specifically.

Comparative study of two digital radiographic storage phosphor systems.

The objective of this study was to evaluate the image quality and dynamic range of two digital radiographic storage phosphor systems: Digora (Soredex, Finland) and DenOptix (Gendex, USA). Four objects were analyzed and eight exposure times employed, totaling 64 images that were analyzed by 5 examiners using a scale from 1 to 4 to classify the images. The scores were submitted to analysis of variance and the results showed statistical differences among the averages attributed to the systems, to the exposition times and to the objects (p 0.01 Pound). Digora presented a larger dynamic range and, in general, a better image quality. Although these 2 systems present the same photon detector, they present different results in relation to the evaluated items.

[Assessment of 3 radiographic methods (conventional periapical, digital periapical, and panoramic) ni the diagnosis of artificially produced periapical lesions]. / Avaliação de três métodos radiográficos (periapical convencional, periapical digital e panorâmico) no diagnóstico de lesões apicais produzidas artificialmente.

This research was carried out in order to evaluate three radiographic methods--conventional periapical, digital periapical and panoramic--in the diagnosis of artificially produced periapical lesions. For this purpose, 5 mandibles, with lesions produced by means of spherical drills of different sizes, were used. The research was divided into five distinct phases, as follows: phase Z (initial)--characterized by the absence of lesion; phase R--lesion produced with a number 6 drill; phase J--lesion produced with a number 8 drill; phase D--lesion produced with a number 10 drill; and phase H--lesion reaching the vestibular cortex. The lesions were produced in quadrants. Radiographs were made after each phase and analyzed by 4 experts in radiology. For the digital system there was statistically significant difference in phase R (in the region of incisors) and in phase H (in the region of premolars). In the region of molars there was statistically significant difference in phase D for panoramic radiography. It must be pointed out that panoramic radiography produced the less effective results in phase H.

[Clinical and comparative study of the image quality of 3 digital radiographic systems, E-speed film and digitalized film]]. / Estudo clínico comparativo da qualidade de imagem de três sistemas radiográficos digitais, filme E-speed e filme digitalizado.

The aim of this study was to evaluate, subjectively, the image quality of two CCD digital systems, a digital storage phosphor system, a digitized film and an E-speed film. Five objects were radiographed with 50, 60 and 70 kVp, with exposure times of 0.08, 0.13, 0.2, 0.4 and 0.8 s. In order to maximize the fidelity of the results, the dental X-ray unit employed was submitted to an evaluation so that the relation between exposure time and dose could be established. A good reproducibility was obtained. Six evaluators analyzed 375 images, using a scoring scale which ranged from 0 to 4. The results revealed different responses, indicating that the storage phosphor system had the best performance, in the various exposures employed. However, it was possible to conclude that all systems studied, except for the Sens-A-Ray, can offer images in ideal conditions for the diagnosis, as long as their latitudes are respected.

Influence of cone beam CT enhancement filters on diagnosis ability of longitudinal root fractures.

OBJECTIVES: To determine whether cone beam CT (CBCT) enhancement filters influence the diagnosis of longitudinal root fractures. METHODS: 40 extracted human posterior teeth were endodontically prepared, and fractures with no separation of fragments were made in 20 teeth of this sample. The teeth were placed in a dry mandible and scanned using a Classic i-CAT® CBCT device (Imaging Sciences International, Inc., Hatfield, PA). Evaluations were performed with and without CBCT filters (Sharpen Mild, Sharpen Super Mild, S9, Sharpen, Sharpen 3 × 3, Angio Sharpen Medium 5 × 5, Angio Sharpen High 5 × 5 and Shadow 3 × 3) by three oral radiologists. Inter- and intraobserver agreement was calculated by the kappa test. Accuracy, sensitivity, specificity and positive and negative predictive values were determined. McNemar test was applied for agreement between all images vs the gold standard and original images vs images with filters (p < 0.05). RESULTS: Means of intraobserver agreement ranged from good to excellent. Angio Sharpen Medium 5 × 5 filter obtained the highest positive predictive value (80.0%) and specificity value (76.5%). Angio Sharpen High 5 × 5 filter obtained the highest sensitivity (78.9%) and accuracy (77.5%) value. Negative predictive value was the highest (82.9%) for S9 filter. The McNemar test showed no statistically significant differences between images with and without CBCT filters (p > 0.05). CONCLUSIONS: Although no statistical differences was observed in the diagnosis of root fractures when using filters, these filters seem to improve diagnostic capacity for longitudinal root fractures. Further in vitro studies with endodontic-treated teeth and research in vivo should be considered.

Clinical and MRI investigation of temporomandibular joint in major depressed patients.

OBJECTIVE: The aim of the present study was to describe the clinical and MRI findings of the temporomandibular joint (TMJ) in patients with major depressive disorders (MDDs) of the non-psychotic type. METHODS: 40 patients (80 TMJs) who were diagnosed as having MDDs were selected for this study. The clinical examination of the TMJs was conducted according to the research diagnostic criteria and temporomandibular disorders (TMDs). The MRIs were obtained bilaterally in each patient with axial, parasagittal and paracoronal sections within a real-time dynamic sequence. Two trained oral radiologists assessed all images. For statistical analyses, Fisher's exact test and χ(2) test were applied (α = 0.05). RESULTS: Migraine was reported in 52.5% of subjects. Considering disc position, statistically significant differences between opening patterns with and without alteration (p = 0.00) and between present and absent joint noises (p = 0.00) were found. Regarding muscular pain, patients with and without abnormalities in disc function and patients with and without abnormalities in disc position were not statistically significant (p = 0.42 and p = 0.40, respectively). Significant differences between mandibular pathway with and without abnormalities (p = 0.00) and between present and absent joint noises (p = 0.00) were observed. CONCLUSION: Based on the preliminary results observed by clinical and MRI examination of the TMJ, no direct relationship could be determined between MDDs and TMDs.

Comparison of digital systems and conventional dental film for the detection of approximal enamel caries.

OBJECTIVES: The aims of this study were (1) to compare the accuracy of the detection of approximal enamel caries lesions using three intraoral storage phosphor plate digital systems and one conventional film-based radiographic system; and (2) to determine whether there is a correlation between the histological and radiographic measurements of enamel caries. METHODS: 160 approximal surfaces were radiographed under standardized conditions using three storage phosphor stimulable systems (DenOptix and Digora FMX with white and blue plates), and one film system (Insight film). 17 observers scored the images for the presence and depth of caries using a 4-point scale. The presence of caries was validated histologically (gold standard). Two-way analysis of variance was used to test the differences in sensitivity, specificity and overall accuracy (TP + TN). The data from the radiographic and histological measurements were statistically analysed by Spearman's rank correlation coefficient. RESULTS: Two-way analysis of variance and the post hoc t-test demonstrated that Digora (white plate) had higher specificity and overall accuracy values than DenOptix (P = 0.021); there was no statistically significant difference among the other imaging modalities (P > 0.05). There was no significant correlation between the histological depth measurements and the radiographic measurements from Digora (blue plate) (P = 0.43), Digora (white plate) (P = 0.15), DenOptix (P = 0.17) and Insight film (P = 0.06). CONCLUSIONS: The results suggest that (1) the performance of the three storage phosphor image plate systems was similar to that of the Insight film for detection of approximal enamel caries, and (2) the increase in histological depth of enamel caries was not significantly correlated with radiographic measurements.

Effect of alternative photostimulable phosphor plates erasing times on subjective digital image quality.

OBJECTIVE: To evaluate the influence of alternative erasing times of DenOptix(R) (Dentsply/Gendex, Chicargo, IL) digital plates on subjective image quality and the probability of double exposure image not occurring. METHODS: Human teeth were X-rayed with phosphor plates using ten different erasing times. Two observers evaluated the images for subjective image quality (sharpness, brightness, contrast, enamel definition, dentin definition and dentin-enamel junction definition) and for the presence or absence of double exposure image. Spearman's correlation analysis and ANOVA was performed to verify the existence of a linear association between the subjective image quality parameters and the alternative erasing times. A contingency table was constructed to evaluate the agreement among the observers, and a binominal logistic regression was performed to verify the correlation between the erasing time and the probability of double exposure image not occurring. RESULTS: All 6 parameters of image quality were rated high by the examiners for the erasing times between 25 s and 130 s. The same erasing time range, from 25 to 130 s, was considered a safe erasing time interval, with no probability of a double exposure image occurring. CONCLUSIONS: The alternative erasing times from 25 s to 130 s showed high image quality and no probability of double image occurrence. Thus, it is possible to reduce the operating time of the DenOptix(R) digital system without jeopardizing the diagnostic task.

Determination of the length of zygomatic implants through computed tomography: establishing a protocol.

OBJECTIVES: The aim of this study was to establish and verify an examination protocol using CT to estimate the length of zygomatic implants, thus rendering the surgical process safer and more predictable, and exposing the patient to a minimal level of radiation. METHODS: Paracoronal CT scan was carried out on ten dry human crania (n = 20) and the zygomatic implant sites were measured (L(CT)) bilaterally. A standard surgical zygomatic implant placement procedure was carried out and the actual lengths (L(Real)) and clinical lengths (L(Clin)) determined. RESULTS: The averages of the L(CT), L(Clin) and L(Real) were 45.73 +/- 4.82 mm, 42.63 +/- 4.33 mm, and 44.73 +/- 4.53 mm, respectively. Student's t-test revealed no statistically significant differences between the L(Real) and L(CT) averages (P = 0.1532), whereas the L(Real) and L(Clin) averages were statistically different (P < 0.0001). CONCLUSIONS: The proposed protocol proved to be precise and efficacious in the determination of zygomatic implant length, with the advantage to the patient of a relatively low level of exposure to radiation due to the small quantity of tomographic slices used. Although there were no major repercussions, the clinical probe in the zygomatic implant kit commonly used in this surgical procedure proved to be a rather imprecise tool.

Comparison of transcranial radiograph and magnetic resonance imaging in the evaluation of mandibular condyle position.

OBJECTIVES: Several image modalities have been used to assess the condylar position in the glenoid fossa. However, despite the development of more advanced techniques for imaging the temporomandibular joint (TMJ), the transcranial projection remains widely used in dentistry. The purpose of this study was to compare the condylar position in transcranial radiography (TRANS) with MRI. METHODS: 70 matched pairs of TMJs (35 patients) who had undergone TRANS and MRI were evaluated. The TRANS scans were compared with the lateral, central and medial MRI scans, and the condylar position was assessed in the closed and open mouth position according to subjective and objective methods. The sensitivity, specificity and accuracy values were calculated for each group and Bowker's test was used to analyse the data. RESULTS: There was no statistical significance between TRANS and MRI (P > 0.05). However, even though there were similar mean values between them, the comparison with the lateral image showed higher values, which might be due to TRANS representing the lateral one-third of the condyle. CONCLUSIONS: It can be concluded that TRANS seems to be an acceptable method and its applicability as an adjunctive method in the condylar position should not be rejected.

The prevalence of bifid mandibular condyle detected in a Brazilian population.

OBJECTIVES: To determine the prevalence of bifid mandibular condyle (BMC) detected on panoramic radiographs in a Brazilian population. METHODS: The panoramic radiographs of 50 080 radiographs taken from 1999 to 2006 were retrospectively reviewed in order to identify BMC cases. RESULTS: 9 (0.018%) of the 50 080 patients, 2 men and 7 women, with age ranging from 20 years to 74 years, had BMC. These conditions were unilateral in 7 (78%) subjects and bilateral in 2 (22%) subjects. All patients denied a history of any previous trauma or fracture of the mandible, pain, or trismus. CONCLUSIONS: BMC is an uncommon finding in a group of Brazilian subjects and, although it is rare, dentists should be aware of this condition on routine panoramic radiographs and its implications for function and appropriate treatment modalities.

Evaluation of temporomandibular joint in stress-free patients.

OBJECTIVES: The aetiology of temporomandibular disorders (TMD) is presently considered to be multifactorial, and stress has been regarded as an important factor in their onset. Many studies have evaluated the importance of stress in TMD; however, only patients with TMD and stress have been assessed. This study aimed at evaluating signs and symptoms of TMD in stress-free patients. METHODS: The temporomandibular joints (TMJs) of 40 stress-free patients were evaluated during clinical examination and in MRI. RESULTS: The individuals lived in an area without electric power supply or telephone services. They worked in agriculture and fishery. 77.5% of the patients presented normal mandibular function; 70% presented normal mandibular trajectory; 61.25% did not present sounds in TMJ and 93.75% did not present joint pain during palpation. Image screening showed that 70% of TMJ presented normal disc position. Only one patient (1.25%) presented TMD. CONCLUSIONS: The absence of stress is a strong factor for the non-development of TMD.

Tonsillolith--report of an unusual case.

Tonsilloliths are rare concretions found in the tonsillar crypt. They are usually single and unilateral, but occasionally may be multiple or bilateral. This report describes a case of a 47-year-old woman whose radiography revealed one radiopaque image located in the right ramus of the mandible. The patient revealed a history of slight dysphagia, halitosis and swallowing pain with a foreign body sensation. Her medical history revealed a tonsillectomy when she was eight years old and the removal of the uvula because of sleep apnoea six years ago. Computer tomography showed a delimited and calcified oval image measuring 0.6 x 0.6 cm. The tonsillar concretion might have been formed because of a calcification of the lymphoid tissue. On the patient's request, surgical excision was not performed and she will be monitored due to the tendency of such lesions to grow.

Comparison of peri-implant bone level assessment in digitized conventional radiographs and digital subtraction images.

OBJECTIVES: Radiographic assessment of marginal bone height is included in longitudinal control of osseointegrated implants. However, accurate and reproducible results are difficult to obtain. The aim of the present study was to examine the differences between linear measurements in digitized radiographs (DR) and digital subtraction images (DSI) around endosseous implants and the interobserver variability. METHODS: The bone height around 30 implants in 22 patients was assessed by 5 observers. Standardized periapical radiographs were obtained just after the surgery and 4 months later. The radiographs were digitized and manipulated by means of EMAGO software, and linear and logarithmic DSIs were produced. Furthermore, the logarithmic subtraction was enhanced with the use of a filter. The observers had the DRs and three methods of subtraction to assess bone height. ANOVA statistical procedures were applied to analyse differences between the observers in the four assessed images and the Tukey test was used to evaluate the differences between the images. RESULTS: Comparison of the bone height assessments indicated significantly (P<0.05) higher values in the DR than the three methods of DSI. The observers also had a statistically significant variability in this assessment (P=0.00003). CONCLUSIONS: DSI demonstrated lower values of linear measurements of the bone height around endosseous implants, compared with DR. Interobserver variability should be considered when comparing values from follow-up studies.