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1.
Drug Dev Ind Pharm ; 50(5): 410-419, 2024 May.
Artigo em Inglês | MEDLINE | ID: mdl-38497274

RESUMO

OBJECTIVES: To develop and evaluate a novel human stratum corneum (SC) mimetic phospholipid vesicle-based permeation assay (PVPASC) model for in vitro permeation studies. SIGNIFICANCE: Due to the increasing restrictions on the use of human and animal skins, artificial skin models have attracted substantial interest in pharmaceuticals and cosmetic industries. In this study, a modified PVPASC model containing both SC lipids and proteins was developed. METHODS: The PVPASC model was optimized by altering the lipid composition and adding keratin in the formulation of large liposomes. The barrier properties were monitored by measuring the electrical resistance (ER) and permeability of Rhodamine B (RB). The modified PVPASC model was characterized in terms of the surface topography, solvent influence and storage stability. The permeation studies of the active components in Compound Nanxing Zhitong Plaster (CNZP) were performed to examine the capability of PVPASC in the application of skin penetration. RESULTS: The ER and Papp values of RB obtained from the optimized PVPASC model indicated a similar barrier property to porcine ear skin. Scanning electron microscope analysis demonstrated a mimic 'brick-and-mortar' structure. The PVPASC model can be stored for three weeks at -20 °C, and withstand the presence of different receptor medium for 24 h. The permeation studies of the active components demonstrated a good correlation (r2 = 0.9136) of Papp values between the drugs' permeation through the PVPASC model and porcine ear skin. CONCLUSION: Keratin contained composite phospholipid vesicle-based permeation assay models have been proven to be potential skin tools in topical/transdermal permeation studies.


Assuntos
Permeabilidade , Fosfolipídeos , Absorção Cutânea , Humanos , Fosfolipídeos/química , Absorção Cutânea/efeitos dos fármacos , Absorção Cutânea/fisiologia , Suínos , Permeabilidade/efeitos dos fármacos , Animais , Lipossomos , Administração Cutânea , Epiderme/metabolismo , Epiderme/efeitos dos fármacos , Pele/metabolismo , Pele/efeitos dos fármacos , Pele Artificial , Rodaminas/farmacocinética , Rodaminas/química , Rodaminas/administração & dosagem
2.
J Prosthet Dent ; 131(5): 917.e1-917.e13, 2024 May.
Artigo em Inglês | MEDLINE | ID: mdl-38443244

RESUMO

STATEMENT OF PROBLEM: A consensus on the optimal approach to the placement of pterygoid implants is lacking. PURPOSE: The purpose of this finite element analysis study was to determine the optimal approach to the placement of pterygoid implants by comparing biomechanical behavior. MATERIAL AND METHODS: An edentulous and moderately atrophic maxilla with the anatomic structure of the pterygomaxillary region was constructed. Complete arch restorations with 4 standard anterior implants and pterygoid implants in 3 approaches were simulated: L70, long pterygoid implants (4.1×18 mm) inclined at 70 degrees relative to the Frankfort horizontal plane with anchorage in the pterygoid process; L45, long pterygoid implants (4.1×20 mm) inclined at 45 degrees with anchorage in the pterygoid process; and S45, shorter pterygoid implants (4.1×13 mm) inclined 45 degrees without apical anchorage. The L70, L45, and S45 groups were classified as D or S depending on the bone quality: D3 (dense trabecular bone) or D4 (sparse trabecular bone). A total of 6 finite element models were built. The bone failure theory, based on the von Mises theory, was used to judge yielding of the trabecular bone. The von Mises stress (σVM) distribution was measured in the cortical bone, the trabecular bone, and on the implant surface. Deformation (DF) distribution was obtained for the entire bone (DFB) and bone surrounding the pterygoid implant (DFP). RESULTS: L70 showed a lower maximum σVM value (maxσVM), more uniform σVM distribution in the cortical bone, trabecular bone, and on the implant surface and a lower maximum DFp value (maxDFp), especially in the D4 bone. The biomechanical behaviors were similar in L45 and S45 with no stress distribution in the pterygoid process. In the D4 bone, L70, L45, and S45 exceeded the limited stress of the bone failure theory by 50%, 130%, and 130%, while all values were under the limit in D3 bone. CONCLUSIONS: The approach of pterygoid implants inclined at 70 degrees relative to the Frankfort plane with anchorage in the pterygoid process was optimal, providing improved biomechanical behavior. Clinically, in the case of D4 bone, the inclined angulation of pterygoid implants should be 70 degrees to minimize the risk of failure.


Assuntos
Implantes Dentários , Análise de Elementos Finitos , Maxila , Humanos , Maxila/cirurgia , Fenômenos Biomecânicos , Implantação Dentária Endóssea/métodos , Osso Esfenoide/cirurgia , Imageamento Tridimensional/métodos , Análise do Estresse Dentário , Arcada Edêntula/cirurgia
3.
J Environ Sci (China) ; 146: 226-236, 2024 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-38969450

RESUMO

Defluoridation of coal mining water is of great significance for sustainable development of coal industry in western China. A novel one-step mechanochemical method was developed to prepare polymeric aluminum modified powder activated carbon (PAC) for effective fluoride removal from coal mining water. Aluminum was stably loaded on the PAC through facile solid-phase reaction between polymeric aluminum (polyaluminum chloride (PACl) or polyaluminum ferric chloride (PAFC)) and PAC (1:15 W/W). Fluoride adsorption on PACl and PAFC modified PAC (C-PACl and C-PAFC) all reached equilibrium within 5 min, at rate of 2.56 g mg-1 sec-1 and 1.31 g mg-1 sec-1 respectively. Larger increase of binding energy of Al on C-PACl (AlF bond: 76.64 eV and AlFOH bond: 77.70 eV) relative to that of Al on C-PAFC (AlF bond: 76.52 eV) explained higher fluoride uptake capacity of C-PACl. Less chloride was released from C-PACl than that from C-PAFC due to its higher proportion of covalent chlorine and lower proportion of ionic chlorine. The elements mapping and atomic composition proved the stability of Al loaded on the PAC as well as the enrichment of fluoride on both C-PACl and C-PAFC. The Bader charge, formation energy and bond length obtained from DFT computational results explained the fluoride adsorption mechanism further. The carbon emission was 7.73 kg CO2-eq/kg adsorbent prepared through mechanochemical process, which was as low as 1:82.3 to 1:8.07 × 104 compared with the ones prepared by conventional hydrothermal methods.


Assuntos
Carvão Vegetal , Minas de Carvão , Fluoretos , Poluentes Químicos da Água , Fluoretos/química , Poluentes Químicos da Água/química , Carvão Vegetal/química , Adsorção , Alumínio/química , Polímeros/química , Purificação da Água/métodos , Eliminação de Resíduos Líquidos/métodos
4.
Mar Drugs ; 21(5)2023 May 14.
Artigo em Inglês | MEDLINE | ID: mdl-37233493

RESUMO

Numerous compounds present in the ocean are contributing to the development of the biomedical field. Agarose, a polysaccharide derived from marine red algae, plays a vital role in biomedical applications because of its reversible temperature-sensitive gelling behavior, excellent mechanical properties, and high biological activity. Natural agarose hydrogel has a single structural composition that prevents it from adapting to complex biological environments. Therefore, agarose can be developed into different forms through physical, biological, and chemical modifications, enabling it to perform optimally in different environments. Agarose biomaterials are being increasingly used for isolation, purification, drug delivery, and tissue engineering, but most are still far from clinical approval. This review classifies and discusses the preparation, modification, and biomedical applications of agarose, focusing on its applications in isolation and purification, wound dressings, drug delivery, tissue engineering, and 3D printing. In addition, it attempts to address the opportunities and challenges associated with the future development of agarose-based biomaterials in the biomedical field. It should help to rationalize the selection of the most suitable functionalized agarose hydrogels for specific applications in the biomedical industry.


Assuntos
Materiais Biocompatíveis , Hidrogéis , Sefarose/química , Hidrogéis/química , Materiais Biocompatíveis/química , Engenharia Tecidual , Sistemas de Liberação de Medicamentos
5.
Molecules ; 28(3)2023 Jan 22.
Artigo em Inglês | MEDLINE | ID: mdl-36770776

RESUMO

Diabetes mellitus is a complicated metabolic disease that has become one of the fastest-growing health crises in modern society. Diabetic patients may suffer from various complications, and diabetic foot is one of them. It can lead to increased rates of lower-extremity amputation and mortality, even seriously threatening the life and health of patients. Because its healing process is affected by various factors, its management and treatment are very challenging. To address these problems, smart biomaterials have been developed to expedite diabetic wound closure and improve treatment outcomes. This review begins with a discussion of the basic mechanisms of wound recovery and the limitations of current dressings used for diabetic wound healing. Then, the categories and characteristics of the smart biomaterial scaffolds, which can be utilized as a delivery system for drugs with anti-inflammatory activity, bioactive agency, and antibacterial nanoparticles for diabetic wound treatment were described. In addition, it can act as a responsive system to the stimulus of the pH, reactive oxygen species, and glucose concentration from the wound microenvironment. These results show that smart biomaterials have an enormous perspective for the treatment of diabetic wounds in all stages of healing. Finally, the advantages of the construction of smart biomaterials are summarized, and possible new strategies for the clinical management of diabetic wounds are proposed.


Assuntos
Diabetes Mellitus , Pé Diabético , Humanos , Materiais Biocompatíveis/uso terapêutico , Pé Diabético/tratamento farmacológico , Cicatrização , Antibacterianos/farmacologia , Antibacterianos/uso terapêutico , Bandagens , Diabetes Mellitus/terapia
6.
Am J Orthod Dentofacial Orthop ; 163(4): 475-482, 2023 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-36564316

RESUMO

INTRODUCTION: For patients with maxillary transverse deficiency, selecting an appropriate therapeutic method is important for the treatment effect and prognosis. Our study aimed to explore factors related to microimplant-assisted rapid palatal expansion (MARPE) in teenagers and young adults using cone-beam computed tomography. METHODS: Twenty-five patients who underwent MARPE were included in this retrospective study from February 2014 to June 2019. Midpalatal suture density (MPSD) ratio, midpalatal suture maturation (MPSM), bone effect, dentoalveolar effect, and dental effect in maxillary first molar were evaluated using cone-beam computed tomography. Spearman correlation analysis was used to analyze the correlation between the MPSD ratio, MPSM, age, and the expansion amount generated by MARPE. RESULTS: Twenty-five patients (mean age, 19.84 ± 3.96 years; range, 15-29 years) with maxillary transverse deficiency were analyzed. Age was negatively correlated with bone expansion, alveolar expansion, and alveolar change (all P <0.05). There was a negative correlation between MPSM and nasal cavity variation, bone expansion, and alveolar change (all P <0.05). The bone expansion was negatively correlated with MPSD ratio 3 (r = -0.417; P <0.05) and MPSD ratio 4 (all P <0.05). CONCLUSIONS: Age, MPSM, and MPSD ratio were significantly related to the MARPE effect. Age, MPSM, and MPSD ratio should be considered when choosing MARPE.


Assuntos
Técnica de Expansão Palatina , Palato , Humanos , Adolescente , Adulto Jovem , Adulto , Estudos Retrospectivos , Palato/diagnóstico por imagem , Tomografia Computadorizada de Feixe Cônico/métodos , Maxila
7.
Zhonghua Yi Xue Yi Chuan Xue Za Zhi ; 40(2): 226-229, 2023 Feb 10.
Artigo em Zh | MEDLINE | ID: mdl-36709946

RESUMO

OBJECTIVE: To explore the clinical phenotype and genetic basis of a neonate with Au-Kline syndrome (AKS). METHODS: Clinical data and result of genetic testing of a neonate with AKS who was admitted to the Affiliated Provincial Children's Hospital of Anhui Medical University in January 2021 were retrospectively analyzed. Relevant literature was searched from the Wanfang Data Knowledge Service Platform, China National Knowledge Infrastructure and PubMed databases using key words "Au Kline syndrome", "Au-Kline syndrome", "HNRNPK" and "AKS". The research period was set as from January 1, 2000 to December 31, 2020. RESULTS: The male newborn has manifested feeding difficulties, hypotonia, absence of the upper jaw to the uvula and facial dysmorphism. Trio-whole exome sequencing revealed that he has harbored a frameshift c.478dupA (p.Ile160AsnfsTer7) variant of the HNRNPK gene, which was varified by Sanger sequencing to have a de novo origin. The variant has not been included in the databases. Based on the guidelines from the American College of Medical Genetics and Genomics, the variant was rated as pathogenic (PVS1+PS2+PM2_Supporting). Literature retrieval has identified 14 children with AKS and de novo mutations of the HNRNPK gene. Their clinical manifestations have included growth and motor retardation, various degree of mental retardation, facial dysmorphism and a high frequency of congenital heart malformations. CONCLUSION: The AKS in this child may be attributed to the c478dupA frameshifting variant of the HNRNPK gene. Diagnosis of AKS should be suspected for children with mental retardation and multiple congenital malformation syndromes including Kabuki syndrome.


Assuntos
Anormalidades Múltiplas , Deficiência Intelectual , Humanos , Masculino , Anormalidades Múltiplas/genética , Testes Genéticos , Ribonucleoproteínas Nucleares Heterogêneas Grupo K/genética , Deficiência Intelectual/genética , Mutação , Estudos Retrospectivos , Recém-Nascido
8.
BMC Oral Health ; 23(1): 319, 2023 05 23.
Artigo em Inglês | MEDLINE | ID: mdl-37221480

RESUMO

BACKGROUND: Pemphigus vulgaris (PV) is a kind of rare and severe autoimmune bullous disease. In this case, the specificity of oral PV lies in the clinical manifestations of a single palatal ulcer, and no blisters were found in the oral mucosa. This case provides a powerful reference for dentists diagnosing and treating oral PV with atypical clinical presentations. CASE PRESENTATION: A 54 years old female patient presented with a non-healing palatal gingival ulcer for over three months. By histopathological H&E staining and the direct immunofluorescence (DIF) test, the final diagnosis was oral PV. After topical glucocorticoid therapy, the affected area was cured. CONCLUSIONS: In patients with prolonged erosion of the skin or oral mucosa, even if complete blisters are not visible, the physician should consider autoimmune bullous diseases and pay attention to avoid diagnostic defects.


Assuntos
Gengivite , Úlceras Orais , Pênfigo , Estomatite , Humanos , Feminino , Pessoa de Meia-Idade , Úlcera , Gengiva
9.
Zhong Nan Da Xue Xue Bao Yi Xue Ban ; 48(2): 302-310, 2023 Feb 28.
Artigo em Inglês, Zh | MEDLINE | ID: mdl-36999478

RESUMO

Palatal radicular groove is a developmental malformation of maxillary incisors, lateral incisors in particular, which often causes periodontal destruction. This paper reports a case of combined periodontal-endodontic lesions induced by palatal radicular groove, which was initially misdiagnosed as a simple periapical cyst. After root canal therapy and periapical cyst curettage, the course of disease was prolonged, resulting in the absence of buccal and maxillary bone plates in the affected tooth area. After the etiology was determined, the affected tooth was extracted and guide bone tissue regeneration was performed at the same time, followed by implantation and restoration at the later stage, leading to clinical cure. The palatal radicular groove is highly occult, and the clinical symptoms are not typical. If the abscess of the maxillary lateral incisor occurs repeatedly, and the abscess of the maxillary lateral incisor has not been cured after periodontal and root canal treatment, cone-beam computed tomographic and periodontal flap surgery should be considered.


Assuntos
Cistos , Cisto Radicular , Humanos , Incisivo , Abscesso , Raiz Dentária/cirurgia , Raiz Dentária/anormalidades , Tratamento do Canal Radicular , Maxila
10.
Small ; 18(22): e2200532, 2022 06.
Artigo em Inglês | MEDLINE | ID: mdl-35318812

RESUMO

Accumulation of snow and ice often causes problems and even dangerous situations for both industry and the general population. Passive de-icing technologies, e.g., hydrophobic, liquid-infused bionic surfaces, have attracted more and more attention compared with active de-icing technologies, e.g., electric heating, hot air heating, due to the passive de-icing technology's lower energy consumption and sustainability footprint. Using passive de-icing coatings seems to be one of the most promising solutions. However, the previously reported de-icing coatings suffer from high ice adhesion strength or short service life caused by wear. An intrinsic self-healing material based on poly-silicone-urea is developed in this work to address these problems. The material is prepared by introducing dynamic disulfide bonds into the hard phase of the polymer. Experimental results indicate that this poly-silicone-urea has a self-healing efficiency of close to 99%. More interestingly, it is found that the coating prepared from this poly-silicone-urea has a super low ice adhesion force, only 7 ± 1 kPa, which is almost the lowest value compared with previous intrinsic self-healing de-/anti-icing reports. This material can maintain low ice adhesion strength after healing. This intrinsic self-healing poly-silicone-urea can meet several practical applications, opening the door for future sustainable anti-/de-icing technologies.


Assuntos
Gelo , Silicones , Humanos , Fenômenos Físicos , Propriedades de Superfície , Ureia
11.
Small ; 18(11): e2107374, 2022 03.
Artigo em Inglês | MEDLINE | ID: mdl-35129310

RESUMO

Specific recognition and strong affinities of bacteria receptors with the host cell glycoconjugates pave the way to control the bacteria aggregation and kill bacteria. Herein, using aggregation-induced emission (AIE) molecules decorated upper critical solution temperature (UCST) polyvalent scaffold (PATC-GlcN), an approach toward visualizing bacteria aggregation and controlling bacteria-polyvalent scaffolds affinities under temperature stimulus is described. Polyvalent scaffolds with diblocks, one UCST block PATC of polyacrylamides showing a sharp UCST transition and typical AIE behavior, the second bacteria recognition block GlcN of hydrophilic glucosamine modified polyacrylamide, are prepared through a reversible addition and fragmentation chain transfer polymerization. Aggregated chain conformation of polyvalent scaffolds at temperature below UCST induces the aggregation of E. coli ATCC8739, because of the high density of glucosamine moieties, whereas beyond UCST, the hydrophilic state of the scaffolds dissociates the bacteria aggregation. The sweet-talking of bacteria toward the polyvalent scaffolds can be visualized by the fluorescent imaging technique, simultaneously. Due to the specific recognition of polyvalent scaffolds with bacteria, the photothermal agent IR780 loaded PATC-GlcN shows the targeted killing ability toward E. coli ATCC8739 in vitro and in vivo under NIR radiation.


Assuntos
Escherichia coli , Polímeros , Polimerização , Temperatura
12.
Mar Drugs ; 20(7)2022 Jun 27.
Artigo em Inglês | MEDLINE | ID: mdl-35877712

RESUMO

An eco-friendly method for ι-carrageenan extraction from seaweed Eucheuma denticulatum through boiling and using a low concentration of Ca(OH)2 is reported. Compared to the traditional method of ι-carrageenan extraction using NaOH, the reported method using Ca(OH)2 had the advantages of using 93.3% less alkali and 86.8% less water, having a 25.0% shorter total extraction time, a 17.6% higher yield, and a 43.3% higher gel strength of the product. In addition, we evaluated the gel properties and structures of ι-carrageenan products extracted by Ca(OH)2 (Ca-IC) and NaOH (Na-IC). The Fourier transform infrared spectroscopy results showed that the structures of Ca-IC and Na-IC did not change remarkably. The results of the thermogravimetric analysis and differential scanning calorimetry showed that Ca-IC had the same thermal stability as Na-IC. The results of the textural analysis showed that Ca-IC had a higher hardness and better chewiness compared to Na-IC. Rheological results indicated that Ca-IC and Na-IC exhibited shear-thinning and non-Newtonian fluid properties, whereas the viscosity of Ca-IC was less than that of Na-IC. In conclusion, this new method of ι-carrageenan extraction using Ca-IC is markedly better and yields higher quality carrageenan than the conventional method of using Na-IC.


Assuntos
Rodófitas , Alga Marinha , Carragenina/química , Rodófitas/química , Hidróxido de Sódio , Viscosidade
13.
Sensors (Basel) ; 22(15)2022 Jul 22.
Artigo em Inglês | MEDLINE | ID: mdl-35897973

RESUMO

This study aims to fabricate smart insoles using wireless Flexi force and bend sensing technology. Polyvinyl chloride (PVC) film was chosen as the substrate to hold all the sensors. The developed smart insole has a three-layer structure (insole-PVC layer-fabric layer) and is calibrated in an isolation laboratory to evaluate its measurement performance. One male volunteer subject exhibited four different body postures, namely tree pose, forward-leaning, squatting, and forward folding pose. Changes in pressure distribution were considered to be similar for the forward, squat, and forward-folded positions. When subjects performed a full squat, the flex sensor exhibited maximum flexion during the squat position, and the flex sensor response against the squat pose was found to be higher by about 18.18% than in the forward lean, respectively. The tree pose has the highest error rate at the first metatarsal, about 18.6%, of which the maximum absolute relative error of the sensor is less than 5%. Plantar pressure distribution and body posture measurements were successfully validated using Flexi force and flex sensors embedded in the smart insole. The smart insole proposed in this research work has broader prospects for clinical application.


Assuntos
, Cloreto de Polivinila , Desenho de Equipamento , Pé/fisiologia , Humanos , Postura/fisiologia , Pressão , Sapatos
14.
J Cell Physiol ; 236(9): 6407-6423, 2021 09.
Artigo em Inglês | MEDLINE | ID: mdl-33559206

RESUMO

Bitter taste receptors (TAS2Rs) and their signaling elements are detected throughout the body, and bitter tastants induce a wide variety of biological responses in tissues and organs outside the mouth. However, the roles of TAS2Rs in these responses remain to be tested and established genetically. Here, we employed the CRISPR/Cas9 gene-editing technique to delete three bitter taste receptors-Tas2r143/Tas2r135/Tas2r126 (i.e., Tas2r triple knockout [TKO]) in mice. The fidelity and effectiveness of the Tas2r deletions were validated genetically at DNA and messenger RNA levels and functionally based on the tasting of TAS2R135 and TAS2R126 agonists. Bitter tastants are known to relax airways completely. However, TAS2R135 or TAS2R126 agonists either failed to induce relaxation of pre-contracted airways in wild-type mice and Tas2r TKO mice or relaxed them dose-dependently, but to the same extent in both types of mice. These results indicate that TAS2Rs are not required for bitter tastant-induced bronchodilation. The Tas2r TKO mice also provide a valuable model to resolve whether TAS2Rs mediate bitter tastant-induced responses in many other extraoral tissues.


Assuntos
Deleção de Genes , Relaxamento Muscular , Receptores Acoplados a Proteínas G/genética , Paladar/fisiologia , Animais , Sequência de Bases , Perfilação da Expressão Gênica , Ligantes , Cloreto de Metacolina/farmacologia , Camundongos Knockout , Contração Muscular/efeitos dos fármacos , Relaxamento Muscular/efeitos dos fármacos , Músculo Liso/efeitos dos fármacos , Músculo Liso/metabolismo , Receptores Acoplados a Proteínas G/metabolismo , Sistema Respiratório/efeitos dos fármacos , Sistema Respiratório/metabolismo , Paladar/efeitos dos fármacos , Língua/efeitos dos fármacos , Língua/metabolismo
15.
Small ; 17(25): e2100956, 2021 06.
Artigo em Inglês | MEDLINE | ID: mdl-34018685

RESUMO

Printed electronics are expected to facilitate the widespread distributed wearable electronics in the era of the Internet of things. However, developing cheap and stable electrode inks remains a significant challenge in the printed electronics industry and academic community. Here, overcoming the weak hydrophilicity of polyaniline, a low-cost, easy-fabricating, and air-stable conducting polymer (CP) ink is devised through a facile assemble-disperse strategy delivering a high conductivity in the order of 10-2 S cm-1 along with a remarkable specific capacitance of 386.9 F g-1 at 0.5 A g-1 (dehydrated state). The additive-free CP ink is directly employed to print wearable micro-supercapacitors (MSCs) via the spray-coating method, which deliver a high areal capacitance (96.6 mF cm-2 ) and volumetric capacitance (26.0 F cm-3 ), outperforming most state-of-the-art CP-based supercapacitors. This work paves a new approach for achieving scalable MSCs, thus rendering a cost-effective, environmentally friendly, and pervasive energy solution for next-generation distributed electronics.


Assuntos
Tinta , Dispositivos Eletrônicos Vestíveis , Condutividade Elétrica , Eletrônica , Polímeros
16.
Med Sci Monit ; 27: e935851, 2021 12 17.
Artigo em Inglês | MEDLINE | ID: mdl-34916481

RESUMO

This publication has been retracted by the Editor due to the identification of non-original figure images and manuscript content that raise concerns regarding the credibility and originality of the study and the manuscript. Reference: Jianping Zhou, Fengxue Yang, Xiaolin Xu, Gang Feng, Jun Chen, Jinglin Song, Hongwei Dai. Dynamic Evaluation of Orthodontically-Induced Tooth Movement, Root Resorption, and Alveolar Bone Remodeling in Rats by in Vivo Micro-Computed Tomography. Med Sci Monit, 2018; 24: 8306-8314. DOI: 10.12659/MSM.912470.

17.
J Environ Sci (China) ; 99: 175-186, 2021 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-33183695

RESUMO

Microalgae and cyanobacteria are fundamental components of aquatic ecosystems. Pollution in aquatic environment is a worldwide problem. Toxicological research on microalgae and cyanobacteria can help to establish a solid foundation for aquatic ecotoxicological assessments. Algae and cyanobacteria occupy a large proportion of the biomass in aquatic environments; thus, their toxicological responses have been investigated extensively. However, the depth of toxic mechanisms and breadth of toxicological investigations need to be improved. While existing pollutants are being discharged into the environment daily, new ones are also being produced continuously. As a result, the phenomenon of water pollution has become unprecedentedly complex. In this review, we summarize the latest findings on five kinds of aquatic pollutants, namely, metals, nanomaterials, pesticides, pharmaceutical and personal care products (PPCPs), and persistent organic pollutants (POPs). Further, we present information on emerging pollutants such as graphene, microplastics, and ionic liquids. Efforts in studying the toxicological effects of pollutants on microalgae and cyanobacteria must be increased in order to better predict the potential risks posed by these materials to aquatic ecosystems as well as human health.


Assuntos
Cianobactérias , Poluentes Ambientais , Microalgas , Poluentes Químicos da Água , Ecossistema , Humanos , Plásticos , Poluentes Químicos da Água/toxicidade
18.
Zhong Nan Da Xue Xue Bao Yi Xue Ban ; 46(6): 666-672, 2021 Jun 28.
Artigo em Inglês, Zh | MEDLINE | ID: mdl-34275937

RESUMO

The precise etiology of oral lichen planus (OLP) is still unclear, but the existing evidence suggests that drug intake, virus infection, fungal infection, psychological disorders, and immunodeficiency are closely associated with the pathogenesis of OLP. We report a case of OLP accompanied with candidiasis induced by long-term use of antimicrobials for recurrent aphthous ulcer (RAU) and update the literature, to discuss the possible association between OLP and misuse of antimicrobials, and to inform general dentists and pharmacists the importance for practice with optimal antimicrobial stewardship. In this case, a 42-year-old man presented to Xiangya Stomatological Hospital with white reticular patterns spreading in the oral cavity for almost 1 year. He was diagnosed with OLP via histopathological examination. He had a 5-year history of RAU which occurred every 1-2 months, and he was given antimicrobials ingested or injected whenever the ulcers came up. Satisfactory treatment results were obtained by stopping the abuse of antimicrobials and local antifungal therapy. Meanwhile, the exacerbation and alleviation of OLP was closely related to the administration of antimicrobials. Combined with literature review, antimicrobial might contribute to the development of OLP by inducing candidiasis, a common side-effect of misuse of antimicrobials. Considering the seriousness of antimicrobial resistance and opportunistic infection, dentists should prescribe antimicrobials judiciously according to guidelines and evidence-based indications. Appropriate prescribing of antimicrobials is a professional responsibility to all dentists.


Assuntos
Líquen Plano Bucal , Micoses , Estomatite Aftosa , Viroses , Adulto , Antifúngicos , Humanos , Líquen Plano Bucal/induzido quimicamente , Líquen Plano Bucal/tratamento farmacológico , Masculino , Estomatite Aftosa/induzido quimicamente , Estomatite Aftosa/tratamento farmacológico
19.
Biochem Biophys Res Commun ; 531(3): 282-289, 2020 10 20.
Artigo em Inglês | MEDLINE | ID: mdl-32800541

RESUMO

B7H3 is a member of B7 family of immunoregulatory transmembrane glycoproteins associated with maintaining immune tolerance, tumor cell proliferation, migration, invasion and metabolism, drug resistance, and stem cell differentiation. Neural crest-derived Multipotent Stem Cells (MSCs) from the dental pulp has become a good choice for tissue regeneration because it is easily obtainable and has strong regeneration potentials. Although there have been many studies investigating the role of B7H3 in cancer cells and immune cells, its role in the dental pulp stem cells regeneration is unknown. In this study, we chose SHEDs (stem cells from human exfoliated deciduous teeth) as a research model to analyze the expression and function of B7H3. The result showed that SHEDs were B7H3/CD90, B7H3/CD73, B7H3/CD105 double positive, and the expression of B7H3 is primarily located within the membrane. Downregulation of B7H3 expression significantly accelerated the expansion of SHEDs through the SHP1/AKT signal axis while upregulation of B7H3 expression decreased the proliferation of SHEDs. Hence, this study indicates that B7H3 is a stem cell surface molecule and might be used as a SHEDs marker whereby its downregulation enhances the proliferation of SHEDs via the activation of B7H3/SHP1/AKT signaling pathway.


Assuntos
Antígenos B7/metabolismo , Técnicas de Silenciamento de Genes , Proteína Tirosina Fosfatase não Receptora Tipo 6/metabolismo , Proteínas Proto-Oncogênicas c-akt/metabolismo , Transdução de Sinais , Membrana Celular/metabolismo , Proliferação de Células , Criança , Pré-Escolar , Humanos , Células-Tronco , Dente Decíduo
20.
FASEB J ; 33(9): 9858-9870, 2019 09.
Artigo em Inglês | MEDLINE | ID: mdl-31166803

RESUMO

Wound healing, especially for diabetic wounds, is a lengthy and complicated process involving interactions and responses at the protein, cell, and tissue levels. Loading of growth factors into a hydrogel to construct a sustained-release system is considered a promising approach to improve wound healing. The present study investigates the effect of thermosensitive heparin-poloxamer (HP) hydrogel-encapsulated recombinant human fibroblast growth factor 21 (rhFGF21) on wound healing in mice with streptozotocin-induced diabetes mellitus. First, we studied the in vitro release of rhFGF21 from the rhFGF21-HP coacervate. The results showed that HP might control the release of rhFGF21. Next, we examined the effect of rhFGF21-HP on skin wound healing in diabetic mice. Our data showed that rhFGF21-HP significantly improved wound closure; promoted granulation, collagen deposition, and re-epithelialization; and enhanced the expression of CD31. Moreover, rhFGF21-HP had obvious advantages in diabetic wound healing. Therefore, the results suggest that the rhFGF21-HP hydrogel polymer plays an important role in skin wound healing. This work provides a suitable sustained-release delivery system that can continuously release rhFGF21 and presents a promising therapeutic strategy for wound healing in patients with diabetes.-Liu, H., Zhao, Y., Zou, Y., Huang, W., Zhu, L., Liu, F., Wang, D., Guo, K., Hu, J., Chen, J., Ye, L., Li, X., Lin, L. Heparin-poloxamer hydrogel-encapsulated rhFGF21 enhances wound healing in diabetic mice.


Assuntos
Diabetes Mellitus Experimental , Fatores de Crescimento de Fibroblastos/farmacologia , Heparina/química , Hidrogéis/química , Poloxâmero/química , Cicatrização/efeitos dos fármacos , Animais , Glicemia , Formas de Dosagem , Liberação Controlada de Fármacos , Fatores de Crescimento de Fibroblastos/administração & dosagem , Fatores de Crescimento de Fibroblastos/química , Teste de Tolerância a Glucose , Humanos , Insulina , Masculino , Camundongos , Camundongos Endogâmicos C57BL , Proteínas Recombinantes
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