Changes in maxillofacial morphology due to improvement of nasal obstruction in rats.

OBJECTIVES: To investigate the effect of release of experimentally introduced nasal obstruction on maxillofacial morphology and percutaneous arterial oxygen saturation (SpO2 ) in rats. MATERIALS AND METHODS: Six-week-old male Wistar rats (n = 36) were divided into a control group (n = 6) and a nasal obstruction group (n = 30). In the nasal obstruction group, the right nostril was occluded with silicon, which was subsequently removed after a given experimental period (days 7, 21, 35, 49 and 63). These animals were then divided into groups D7, D21, D35, D49 and D63 (each n = 6), according to the day at which the obstruction was released. The SpO2 was measured in rats with nasal obstruction at five experimental points. The maxillofacial morphology in rats on the first day and 63 days after the start of the experiment was evaluated by microcomputed tomography. RESULTS: The SpO2 was still lower at 2 weeks after the improvement of the nasal obstruction in the D49 group than in the control group. In addition, the height of the nasal maxillary complex of the D35, D49 and D63 groups was significantly decreased compared with the control group. CONCLUSIONS: The results of this study suggest that long-term unilateral nasal obstruction in growing rats may affect the growth of the nasomaxillary complex and reduce the SpO2 permanently. Therefore, early improvement of nasal obstruction in rats during the growth period may improve the SpO2 and cranial development and promote normal growth and development.

Unilateral nasal obstruction induces degeneration of fungiform and circumvallate papillae in rats.

BACKGROUND: In clinical orthodontic treatment, chronic respiratory disturbance or mouth breathing has been concerned symptoms and screening criteria. In this study, to analyze the relation between nasal obstruction and taste sensing, a unilateral nasal obstruction model was performed to investigate the taste papillae and taste buds in rats. METHODS: Fourteen 6-day-old male Wistar rats were randomly divided into control and experimental groups (n = 7 each). The experimental group underwent unilateral nasal obstruction at 8 days of age. The rats were euthanized at 9-week-old. The morphology of the circumvallate papillae and taste buds were identified by immunohistochemical methods. The fungiform papillae were visualized with 1% methylene blue and sectioned for taste bud observation. RESULTS: Some defects in the gustatory epithelium were observed after unilateral nasal obstruction. Rats in the experimental group had significantly fewer fungiform papillae and smaller volumes of taste bud. In circumvallate papillae, smaller total taste bud area was found in experiment group. CONCLUSION: Findings in the present study suggest that nasal obstruction might have significant influences on the gustatory function via morphologic change in the taste papillae and taste buds in tongue area.

Effects of surgical treatment of hypertrophic turbinates on the nasal obstruction and the quality of life.

PURPOSE: Chronic hyperplasia of the inferior nasal concha is accompanied by a nasal obstruction; however, there is no standardised surgical treatment for this condition. Here, we compared the outcome of three surgical techniques frequently used to treat the hyperplasia of inferior turbinates: turbinectomy with lateralization, submucosal electrocautery and laser cautery additional to septoplasty. MATERIALS AND METHODS: One hundred and nine patients participated in this prospective randomized study upon signing written consent. The subjects were randomly assigned to one of three intervention groups: 1) submucosal turbinectomy with lateralization, 2) submucosal electrocautery or 3) laser cautery. All groups were followed-up for up to 6months after surgical intervention. During the four follow-up appointments, the outcomes were measured with the modified German version of Sino-Nasal Outcome Test 20 questionnaire. In addition, the nasal breathing and the absolute nasal flow rates and respective mucosal component were determined by the anterior rhinomanometry. RESULTS: Following surgery, the subjective and objective nasal obstruction decreased significantly in all three groups. Moreover, the subjective symptoms measured by modified Sino-Nasal Outcome Test 20 improved significantly, although there were some temporal differences between groups regarding subjective nasal obstruction, ear pressure, nasal discomfort, daytime fatigue, cough and dry mouth. The mucosal component of nasal congestion decreased significantly after surgery. CONCLUSIONS: All surgical techniques used to reduce the conchae mucosa led to a significant improvement in the objective and subjective nasal breathing and the quality of life. Septoplastic reduction proved to be of additional benefit.

Importance of a multidisciplinary approach and monitoring in fetal warfarin syndrome.

Warfarin is a synthetic oral anticoagulant that crosses the placenta and can lead to a number of congenital abnormalities known as fetal warfarin syndrome. Our aim is to report on the follow-up from birth to age 8 years of a patient with fetal warfarin syndrome. He presented significant respiratory dysfunction, as well as dental and speech and language complications. The patient was the second child of a mother who took warfarin during pregnancy due to a metallic heart valve. The patient had respiratory dysfunction at birth. On physical examination, he had a hypoplastic nose, pectus excavatum, and clubbing of the fingers. Nasal fibrobronchoscopy showed upper airway obstruction due to narrowing of the nasal cavities. He underwent surgical correction with Max Pereira graft, zetaplasty, and osteotomies for the piriform aperture. At dental evaluation, he had caries and delayed eruption of the upper incisors. Speech and language assessment revealed high palate, mouth breathing, little nasal patency, and shortened upper lip. Auditory long latency and cognitive-related potential to auditory stimuli demonstrated functional changes in the cortical auditory pathways. We believe that the frequency of certain findings observed in our patient may be higher in fetal warfarin syndrome than is appreciated, since a significant number result in abortions, stillbirths, or children evaluated in the first year of life without a follow-up. Thus, a multidisciplinary approach and long-term monitoring of these patients may be necessary.

The effect of the duration of merocel in a glove finger on postoperative morbidity.

We examined the effects of the duration of keeping a Merocel nasal packing in the nose and the application technique (packing applied either directly or inside a glove finger) on postoperative morbidity and complications. The study included 129 patients (67 males and 62 females; age range 18 to 56 years) undergoing nasal septoplasty without turbinate intervention. The patients were randomly assigned into 4 groups. In group 1 and group 2, Merocel was directly applied in the nasal cavity for 24 hours and 48 hours, respectively; in group 3 and group 4, Merocel was kept in the nasal cavity in a powder-free glove finger for 24 hours and for 48 hours, respectively. Pain and discomfort scores were evaluated by a visual analog scale. The time taken between removal of the tampon and when the patients began to breathe comfortably was called the nasal obstruction time. The differences in mean discomfort score between the groups were not statistically significant (P > 0.05), while the mean pain scores were statistically higher in groups 1 and 2 than in groups 3 and 4 (P < 0.05). The nasal obstruction time was statistically shorter in groups 2 and 4 than in groups 1 and 3 (P < 0.05). Therefore, keeping Merocel inside a glove finger in place for 48 hours notably reduces the pain occurring during the removal of the nasal tampon. It also reduces nasal obstruction time and prevents synechia, leakage, bleeding, and septal hematoma, without compromising patient comfort.

[Relationships between the dental arches measurements and the peak nasal inspiratory flow (PNIF): a cross sectional study on 78 Senegalese teenagers]. / Relations entre les mensurations des arcades dentaires et le débit nasal inspiratoire de pointe: etude transversale sur 78 adolescents Senegalais.

INTRODUCTION: Upper airways obstruction can result in the reduction of the transversal dimensions of the maxillary arch which affect the vertical and the sagittal dimensions. The PNIF measure is an objec- tive and cheap way to assess the upper airways permeability. The aim of this study was to determine the relationship between PNIF and dental arch sizes. MATERIALS AND METHODS: Seventy eight patients (40 girls and 38 boys) age ranged 10-15 years were included in this cross sectional study. The PNIF was measured with a Youlten peak flow meter (Clement Clarke International, London, United Kingdom). The sagittal, vertical and transversal dimensions of the dental arches were evaluated on dental casts with a digital caliper (Mitutoyo Corporation, Tokyo, Japan). T test was used to assess differences in PNIF and dental arches variables between subjects grouped according to sex (male and female). The Pearson's correlation coefficient was used to analyze the relationship between the dental arches sizes and the PNIF. The significance was set at p < 0.05. RESULTS: PNIF rate was higher in girls than in boys but the difference was not significant. There were sexual dimorphism regarding the anterior and total lengths of the upper arch, the total length of the lower arch and the maxillary intermolar width which are significantly more important for boys (p respectively equal to 0.05; 0.03; 0.04 and 0.04). The PNIF was significantly and negatively correlated with the total length of the upper arch (r = -0.25). The others measurements did not show significant correlation with PNIF. CONCLUSION: Others parameters are needed to complement the peak nasal inspiratory flow rate for the respiratory disorders related dental arches sizes abnormalities diagnosis.

Improvement of nasal airway ventilation after rapid maxillary expansion evaluated with computational fluid dynamics.

INTRODUCTION: Rapid maxillary expansion is known to improve nasal airway ventilation. However, it is difficult to precisely evaluate this improvement with conventional methods. The purpose of this longitudinal study was to use computational fluid dynamics to estimate the effect of rapid maxillary expansion. METHODS: Twenty-three subjects (9 boys, 14 girls; mean ages, 9.74 ± 1.29 years before rapid maxillary expansion and 10.87 ± 1.18 years after rapid maxillary expansion) who required rapid maxillary expansion as part of their orthodontic treatment had cone-beam computed tomography images taken before and after rapid maxillary expansion. The computed tomography data were used to reconstruct the 3-dimensional shape of the nasal cavity. Two measures of nasal airflow function (pressure and velocity) were simulated by using computational fluid dynamics. RESULTS: The pressure after rapid maxillary expansion (80.55 Pa) was significantly lower than before rapid maxillary expansion (147.70 Pa), and the velocity after rapid maxillary expansion (9.63 m/sec) was slower than before rapid maxillary expansion (13.46 m/sec). CONCLUSIONS: Improvement of nasal airway ventilation by rapid maxillary expansion was detected by computational fluid dynamics.

A huge midline premaxillary cyst as a late complication of maxillary surgery.

A median palatal cyst is an uncommon nonodontogenic cyst, and patients usually present with a painless swelling or the sensation of a mass. The mass is typically a well-defined fixed swelling along the midline. The mass can cause slight elevation of the nasal floor or swelling and drainage from the hard palate. Surgical resection is usually recommended as a definite treatment.We treated a 30-year-old man with a premaxillary mass with nasal obstruction. He had undergone surgery on both the maxilla and the mandible to correct malocclusion 10 years earlier. A physical examination revealed elevated mucosa of the nasal floor, resulting in near-total obstruction of the nasal cavity, and the gingival mucosa over the upper incisors was also swollen. Preoperative computed tomographic scan demonstrated a midline nonenhancing round cystic lesion in the premaxillary area. Surgical excision was performed via a sublabial approach under general anesthesia, and his recovery after surgery was uneventful.

Does nasal obstruction affect the articulation of plosive consonants?

OBJECTIVES: In this study, we investigated the impact of chronic nasal obstruction on articulation of the Turkish voiceless plosive (stop) consonants and examined the effect of the nose- and mouth-breathing on the articulatory characteristics of the specific speech sounds. PATIENTS AND METHODS: Twenty-one controls with nose-breathing and 20 patients with mouth breathing were included in this study. The nasal obstruction history of the patients was 10 to 22 years. In the mouth-breather group, intranasal pathologies except septal deviation and turbinate hypertrophy were excluded. The nose-breather subjects without nasal pathologies served as the control group. The subjects graded nasal obstruction through visual analog scale (VAS) from 0 to 10. The minimal cross-sectional area (MCA) and minimal cross-sectional volume (MCV) at the level of septal tubercle and the head of inferior turbinate were established to be 1 and 2 by acoustic rhinometry. Minimal cross-sectional volume was defined as the volume below the curve. The syllables [pa], [ta], [ka] uttered by the subjects were recorded for the spectrographic analysis. Voice onset time (VOT) was measured on wide-band spectrogram. RESULTS: The VOT value of /p/ was found lower and the VOT values for /t/ and /k/ were found higher in mouth-breathers compared to nose-breathers, while the difference was not statistically significant. The right and left-sided VAS values of the nasal obstruction group were significantly higher compared to controls (p=0.001). The right and left-sided MCA1, MCA2, MCV1 and MCV2 were found statistically different between the two groups. CONCLUSION: It was concluded that the articulation features of plosive consonants were not significantly affected by nasal obstruction.

[An unusual localization of fungiform papilloma].

In this article, we presented a 54-year-old male who was admitted with complaints of nasal obstruction with snoring and mouth breathing for one year. Anterior rhinoscopy revealed a mass arising from the inferior nasal concha on the left side. After computed tomography evaluation, endoscopic examination and incisional biopsy, the mass was removed en bloc endoscopically. The histopathological analysis resulted in a diagnosis of a fungiform papilloma. Fungiform papillomas arise almost exclusively on the nasal septum, while inverted papillomas predominantly affect the lateral nasal wall. To our knowledge, no previous report of fungiform papilloma involving the inferior concha has been published in the English literature.

[Cephalometric characteristics of black African children 3-6 years of age with nasal obstruction]. / Caractéristiques céphalométriques chez l'enfant mélano-africain âgé de 3 à 6 ans avec obstruction du cavum.

OBJECTIVE: To determine the cephalometric craniofacial characteristic of the child with chronic rhinopharyngeal obstruction. MATERIAL AND METHODS: It is about a comparative cross-sectional study with etiologic aiming including children of the 2 sexes, old from 3 to 6 years. The pathological subjects are represented by those presenting a chronic rhinopharyngeal obstruction due to the presence of hypertrophied tonsils (n = 29) and the "normal" subjects, those without any rhinopharyngeal obstruction (n = 30). Lateral cephalometric radiographs were obtained for each subject. The conventional landmarks were determined with the subject's head in neutral position. The two groups underwent cephalometric measurements. The cephalometric analysis was made starting from conventional landmarks resulting from soft tissues and osseous structures. Various statistical tests (test t of student, test of Kruskal Wallis, test of Mann-Whitney) were used for the exploitation of the cephalometric data. RESULTS: On the skeletal level, the length of the posterior cranial base was shorter at the pathological subjects than at the healthy subjects. Concerning the mandible, the height of the ramus and the length of the mandibular corpus are also weaker at the pathological subjects than at the witnesses. The hyoid bone is further away from the 3rd cervical vertebra and the craniocervical angle is more open at the pathological subjects, representing a modification of the slope of the cervical column. On the level of the rhinopharyngeal space, the average distances from the posterior nasal spine at the posterior edge of the rhinopharyngeal space and between the posterior nasal spine and the posterior base of the base of cranium are respectively of 19,43 +/- 4,78 mm and 37,56 +/- 2,95 mm. These measurements are not significantly different from those described in the literature. CONCLUSION: Our study highlighted skeletal modifications in children presenting a rhinopharyngeal obstruction. Even if they do not justify all the symptoms met, these modifications can represent a readjustment of the pharyngeal corridor aiming at facilitating the flow of airflow.

Use of intranasal submucosal fillers as a transient implant to alter upper airway aerodynamics: implications for the assessment of empty nose syndrome.

BACKGROUND: Empty nose syndrome (ENS) is a debilitating condition associated with inferior turbinate tissue loss. Surgical augmentation of the inferior meatus has been proposed to treat ENS, although efficacy data with validated, disease-specific questionnaires is limited. Instead we evaluated submucosal injection of a transient, resorbable filler into the inferior meatus to favorably alter nasal aerodynamics in ENS patients. METHODS: Patients with a history of inferior turbinate reduction, diagnosed with ENS via Empty Nose Syndrome 6-Item Questionnaire (ENS6Q) and cotton testing, were enrolled and underwent submucosal injection of carboxymethylcellulose/glycerin gel (Prolaryn®) into the inferior meatuses between July 2014 and May 2018. This material likely resorbs over several months. Outcomes included comparisons of preinjection and postinjection symptoms at 1 week, 1 month, and 3 months using the ENS6Q, 22-item Sino-Nasal Outcome Test (SNOT-22), Generalized Anxiety Disorder 7-item scale (GAD-7), and Patient Health Questionnaire-9 (PHQ-9). RESULTS: Fourteen patients underwent injections. Mean ENS6Q scores significantly decreased from baseline at 1 week (20.8 vs 10.5; p < 0.0001), and remained reduced but upward-trending at 1 month (13.7, p = 0.002) and 3 months (15.5, p > 0.05) following injections. Mean SNOT-22 scores significantly decreased at 1 week (p = 0.01) and 1 month (p = 0.04), mean GAD-7 at 1 month (p = 0.02) and 3 months (p = 0.02), and mean PHQ-9 at 1 week (p = 0.01) and 1 month (p = 0.004) postinjection. CONCLUSION: Transient, focal airway bulking via submucosal filler injection at sites of inferior turbinate tissue loss markedly benefits ENS patients, suggesting that aberrant nasal aerodynamics from inferior turbinate tissue loss contributes to (potentially reversible) ENS symptoms.

Effect of an intra-oral nasal dilation appliance on 3-D nasal airway morphology in adults.

To determine the effects of a nasal dilation appliance on 3-D nasopharyngeal airway patency. The sample comprised 187 adults (98 males, 89 females) with a history of sleep-disordered breathing. Acoustic rhinometry readings were taken from all patients before and after the intra-oral placement of a nasal dilation appliance (OASYS). The mean left and right nasopharyngeal airways were reconstructed in 3-D, and the data from the right and left nostrils were subjected to principal components analysis (PCA) and finite-element scaling analysis (FESA). Comparing the pre- and post-treatment 3-D mean, left nasopharyngeal airways using PCA, the first two eigenvalues accounted for 96% of the total shape change, and statistical differences were found (p < 0.01). Similarly, for the right side, significant differences were detected between the mean pre- and post-treatment 3-D nasopharyngeal airways (p < 0.01) using PCA. Using FESA to quantify and localize changes after the placement of the nasal dilation appliance, the 3-D mean, normalized, left nasopharyngeal airway was found to be 14% wider in the anterior nasal valve region and 28% wider in the distal regions, while the 3-D mean, normalized, right nasopharyngeal airway was 13% wider in the anterior nasal valve region and 27% wider further distally. The use of an intra-oral nasal dilation appliance may be useful in the management of nasopharyngeal conditions, such as snoring, upper airway resistance syndrome, sleep-disordered breathing, and obstructive sleep apnea, especially in cases where nasal obstruction is demonstrable.

Soft tissue profile of children with impaired nasal breathing.

UNLABELLED: The aim of the study was to evaluate soft tissue profile of the children with impaired nasal breathing. MATERIALS AND METHODS: Soft tissue points relative to the true vertical line (TVL) were measured on the lateral cephalograms in natural head position of 54 subjects with diagnosed nasal obstruction (34 males, 20 females, mean age 13.3+/-2.7). As controls served 33 patients receiving orthodontic treatment for different types of malocclusion (19 males, 14 females, mean age 13.4+/-2.7). Nasal airflow measurements were performed for all children. RESULTS: Both groups had retrognathic soft tissue profile, and there were no statistically significant difference between the groups in the linear and angular measurements of the soft tissue measurements, except for the interlabial gap measurement. Soft tissue profile projections to TVL were dependent on craniocervical and cervical inclination angles. In addition head extension was associated with flattened mentolabial sulcus and increased lower face height. Some of the soft profile measurements correlated with age. CONCLUSION: Soft tissue profile of the children with impaired nasal breathing in general is not different from the soft tissue profile of other orthodontic patients and mostly is dependent on the craniocervical posture and age.

Comparison between radiological and nasopharyngolaryngoscopic assessment of adenoid tissue volume in mouth breathing children.

The pharyngeal tonsil (adenoid) constitutes the upper portion of the Waldeyer's ring and is located at the top of the nasopharynx, next to the auditory tube and choana. It plays an important role in recurrent otitis of the middle ear and many times its enlargement is responsible for upper airway obstruction. Tonsillectomy is often the treatment of choice for tonsillar diseases. So far, it is the most frequent and one of the oldest surgical procedures performed in children and young adults. The criteria for tonsillectomy, its effect on patient's immunological integrity and the surgical risks are widely controversial. Image study using paranasal sinuses x-ray is a very simple, easy and comfortable method to evaluate the sizes of adenoids and the grade of upper airway obstruction. Cohen et al. supported that paranasal sinuses x-ray is the best way to determine pharyngeal tonsil hypertrophy. On the other hand, nasopharyngolaryngoscopy can provide more accurate data on the nasopharynx, as it can dynamically reveal its structures and the obstruction status of the upper airway. This study compared the grade of adenoid hypertrophy, as well as upper airway obstruction, using the above-mentioned approaches in children ranging from 3 to 10 years old. The study came to the conclusion that nasopharyngolaryngoscopy is a much more accurate diagnostic procedure than radiological evaluation of the nasopharynx.

Resection of a juvenile nasoangiofibroma by Le Fort I osteotomy: Experience with 40 cases.

PURPOSE: The aim of this study was to determine the rate of success and complications of juvenile nasoangiofibroma resection by Le Fort I osteotomy. MATERIAL AND METHODS: Data were obtained from the medical records of 40 patients with a diagnosis of juvenile nasoangiofibroma confirmed by anatomopathological examination. All tumors were resected by Le Fort I osteotomy between 1983 and 2010. The data obtained were gender, age, symptoms, sites of invasion, preoperative embolization, routes of surgical access, duration of surgery, complications, need for transfusion, relapses, and follow-up time. RESULTS: All patients were male, ranging in age from 7 to 27 years. The most common symptom was nasal obstruction, and central nervous system (CNS) invasion was present in 27.5% of cases. Craniotomy was associated with Le Fort I osteotomy in only one case. The mean duration of surgery was 216 min. Complications occurred in 15% of cases, with intraoperative bleeding being the most frequent one. Relapses occurred in 5% of cases. The mean follow-up was 48.8 months. CONCLUSION: Exclusively surgical treatment by Le Fort I access proved to be a safe and effective method for the treatment of nasoangiofibromas, permitting the removal of tumors even in patients with extension to the CNS, with a low rate of complications and relapses.

Giant cell reparative granuloma of the nasal cavity.

We report an unusual case of giant cell reparative granuloma (GCRG) arising in the nasal cavity of a 7-year-old girl. GCRG is an uncommon benign lesion that is most commonly found in the mandible and maxilla. The MR imaging and CT findings of this lesion, as well as GCRGs in other craniofacial bones and extragnathic sites, will be reviewed. Although rare, the imaging characteristics of GCRGs should be recognized, and this entity should be suggested when the clinical information, CT, and MR features suggest a fibrous-osseous lesion in the nasal cavity.