Retrospective review of pediatric oral lesions from a dental school biopsy service.

UNLABELLED: This report presents a review of the results from 5457 biopsies of patients, 0-16 years of age, received over 15 years at the University of the Pacific School of Dentistry (Pacific Oral and Maxillofacial Pathology Laboratory). PURPOSE: To carry out the largest and most up to date U.S. survey of oral specimens from children. METHOD: The computerized data was retrieved and compiled for age and diagnoses. The lesions were divided by the MIND classification system into 1) Metabolic 2) Inflammatory 3) Neoplastic and 4) Developmental. RESULTS: Inflammatory lesions formed the largest group of biopsies (2758, 51%) followed by Developmental conditions (1928, 35%) and Neoplasms (734, 13%). Dentigerous cysts were the most common lesions, followed by the mucous retention phenomenon (mucocele). The 15 most frequently occurring lesions accounted for 80% of all biopsies. Eight malignancies and 22 benign aggressive tumors were also included. CONCLUSIONS: 1. Pathoses increase with age. 2. Results from our study are similar to most of the other studies. 3. More serious pathoses occur in some countries where there is limited access to care, resulting in patients seeking care only when symptomatic. 4. Oral malignancies are rare, but as with any malignancy, early diagnosis renders a more favorable prognosis.

The prevalence of oral mucosal lesions in adults from the Turin area.

AIM: To assess the prevalence of oral mucosal lesions (OML) and evaluate its association with tobacco and alcohol consumption and the wearing of removable dentures in an adult population from the Turin area, Italy. MATERIALS AND METHODS: A retrospective study, based on an invitational self-selected screening, was performed on 4098 subjects. It included clinical examination plus biopsies when necessary. Patient history included age, sex, denture wearing and risk habits. Internationally accepted criteria were adopted to classify the OMLs. RESULTS: Males were observed to have more OMLs (557/2040; 27.3%vs 471/2058; 22.89%). Overall OML prevalence was linked to risk habits and age. Tobacco was linked to leukoplakia, melanin pigmentation, smoker's palate, frictional lesions and papilloma. It was negatively related to recurrent aphthous stomatitis and oral lichen planus. Alcohol was linked to leukoplakia, frictional lesions and median rhomboid glossitis. The tobacco-alcohol association was linked to frictional lesions, leukoplakia, melanin pigmentation and smoker's palate. Denture wearers had an overall higher prevalence of OMLs, in particular candidiasis, traumatic and frictional lesions. CONCLUSIONS: The prevalence of OMLs in Turin seems to be comparable to those in other European studies and emphasize that risk habits and denture wearing have some relationship with the presence of OMLs.

A survey of oral and maxillofacial pathology specimens submitted by general dental practitioners over a 30-year period.

OBJECTIVES: To determine the range and frequency of diagnoses in specimens submitted for histopathological examination by general dental practitioners (GDPs). METHODS: A retrospective analysis was carried out of all cases submitted by GDPs for the period 1974-2003, using a Foxpro Windows database. The data were collated into 10 diagnostic categories each comprising number of diagnoses, percentage of each diagnosis within a diagnostic category and each diagnosis as a percentage of total cases. RESULTS: GDPs submitted 6,666 cases out of a total of 53,474 for this period. While the total number of specimens increased four-fold over the 30-year period, specimens from GDPs increased from 7% to 17%. The range of diagnoses increased from 18 to 45. Of the 617 GDPs who submitted material, 279 (45%) submitted less than two specimens each in 30 years. Nine malignant neoplasms were diagnosed. Other significant pathology included 320 benign neoplasms as well as diagnoses ranging from mucosal lesions such as lichen planus to odontogenic cysts. CONCLUSIONS: It is clear that GDPs have provided an increased number of biopsy specimens over the last three decades. This reflects an increasing demand by GDPs for a diagnostic oral histopathology service and their use of this service should be encouraged.

Prevalence of oral lesions in HIV patients related to CD4 cell count and viral load in a Venezuelan population.

AIM: To determine the prevalence of oral lesions in a HIV+ group of patients, related to CD4 cell count and viral load in a Venezuelan population. MATERIALS AND METHODS: In the present study, we evaluated 75 HIV+ adult patients, attended at the Center of Infectious Diseases, at the Faculty of Dentistry, Central University of Venezuela. Each patient was clinically examined for detection of oral mucosal lesions. In addition, CD4 cell count was determined by flow cytometry, as well as viral load by RT-PCR (Amplicor HIV-RNA, TM test 1.5, Roche). RESULTS: 85% (64/75) of HIV/AIDS patients showed associated HIV lesions. Oral Candidiasis constituted the most common lesion representing a 61% (39/64), followed by Oral Hairy Leukoplakia 53% (34/64); Oral Leukoplakia 34% (22/64), Melanic Hyperpigmentation 38% (18/64); Papilloma 13 (6/64), Lineal Gingival Erythema 8% (5/64); Aphtous Recurrent Stomatitis 5% (4/64) and Kaposi's Sarcoma 5% (3/64). Only one case of the following lesions were represented by Non Hodgkin Lymphoma, Multifocal Epithelial Hyperplasia, Recurrent Herpes, Histoplasmosis and Molluscum Contagiosum. The patients with a viral load of 30.000 copies/mm3 exhibited oral lesions related with HIV, independent of CD4 cell count, although patients with CD4+ levels of 200 cel/mm3 were more susceptible to develop these lesions. CONCLUSIONS: The most common oral lesion was Oral Candidiasis followed by Oral Hairy Leukoplakia, Oral Leukoplakia and Melanic Hyperpigmentation. A high viral load was strongly associated to the oral lesions occurrence independently of CD4+ cell count.

A survey of localized lesions of oral tissues: a clinicopathological study.

OBJECTIVE: The purpose of this study was to establish the relative prevalence of the different histopathological aspects of biopsied localized soft tissue oral lesions in a university-based dental school biopsy service. STUDY DESIGN: A retrospective analysis of patients' records with localized lesions treated in the Department of Oral Medicine and Oral Surgery between 2001 and 2004 was conducted. The lesions were classified into either fibrous lesions or soft hemorrhagic lesions. Clinical data regarding age, gender, location, and treatment of the lesions were obtained for each case. RESULTS: The majority of the lesions were located in the gingiva. There were a total of 294 cases of which 182 (61.9%) were fibrous lesions and 112 (38.1%) were soft hemorrhagic lesions. All cases were treated by excisional biopsy and elimination of the chronic irritant. CONCLUSION: Although this data might be used as a guide for forming clinical impressions about oral lesions, the clinician must always be aware of the possible occurrence of more rare lesions. This study indicates there are some differences in age and gender distribution as well as in location between the different lesions.

Inverting papilloma of the head and neck: the UCLA update.

Inverting papilloma of the nose and paranasal sinuses is a benign disease with malignant potential. This disease is characterized by multiple recurrences, especially after minimal operative therapy. Controversy exists over the most appropriate treatment for this rare tumor. This review presents an update of the UCLA experience with inverting papilloma over the past four decades along with a review of the literature. A retrospective study of 61 patients seen at the UCLA Medical Center was conducted. The mean age at presentation was 63 years, with a male-to-female ratio of 2:1. The most common symptom at presentation was nasal obstruction (71%), followed by epistaxis (27%). Seventeen percent of the patients in this series either had concurrent squamous cell carcinoma of the nose or paranasal sinuses, or it developed. Patients treated with a lateral rhinotomy and medial maxillectomy had a recurrence rate of 30 percent. Those treated with a less aggressive operation had a recurrence rate of 71 percent. Despite a trend for a more conservative sinus operation in recent literature, we continue to advocate a lateral rhinotomy and medial maxillectomy as the treatment of choice for inverting papilloma of the head and neck.

Oral tumours in Tanzanian children based on biopsy materials examined over a 15-year period from 1982 to 1997.

AIM: To provide information on the types and distribution of oral tumours and tumour-like lesions occurring in a Tanzanian child population aged 0-16 years. DESIGN: Retrospective study of biopsy results from hospital records from 1982-1997. SETTING: Department of Histopathology, the Muhimbili Medical Centre (MMC) in Dar es Salaam. INTERVENTION/ METHODS: A total of 158 biopsy results, from 75 girls and 83 boys, were retrieved and studied. RESULTS: Malignant tumours were the most frequent (43.0%) followed by benign tumours (30.4%) and tumour-like lesions (26.6%). Burkitt's lymphoma was the most frequent malignant tumour accounting for 88.2% of all malignancies followed by squamous cell carcinoma (4.4%) and oral Kaposi's sarcoma (2.9%). Fibroma, papilloma and haemangioma were the most frequent benign tumours constituting 27.1%, 14.6% and 12.5%, respectively. Odontogenic cysts were the most frequent tumour-like lesions (28.6%) followed by fibrous dysplasia (19%) and giant cell granuloma (16.7%). CONCLUSION: The six most common oral lesions were Burkitt's lymphoma, fibroma, odontogenic cysts, fibrous dysplasia, papilloma and giant cell granuloma.

Prevalence of oral lesions in a selected Vietnamese population.

Clinical examination of the oral and peri-oral regions of a cohort of 550 Vietnamese living in a refugee camp in Hong Kong was conducted. They comprised 216 (39 per cent) males and 334 (61 per cent) females and their age ranged from 2 to 60 years. A positive clinical finding was observed in 14 per cent, 35 males and 43 females. The most common condition observed was periapical infection (36 per cent), either with an abscess or a sinus. Other lesions noted include mucocele (10 per cent), traumatic ulcers (9 per cent), tori, either palatal (6 per cent) or mandibular (3 per cent), lymph node enlargement (7 per cent), pulp polyp (6 per cent), angular cheilitis (4 per cent), papillomas (3 per cent), cellulitis (3 per cent) and herpes lesions (2 per cent), 7 out of 9 (78 per cent) mucoceles were found in females. No malignant lesions were noted.

Pediatric oral lesions: a 15-year review from São Paulo, Brazil.

There are few studies on pediatric oral pathologies in the literature. This study presents data from a review of 2,356 biopsies of young patients (birth to 14 years) received over 15 years (1985-2000) in the Oral Pathology Service at the University of Sao Paulo, Brazil. Information about patients (sex, age, race) and histopathological diagnosis was retrieved. Diagnosis data of 2,356 biopsies were classified into 20 groups. There was no significant difference between male (50.0%) and female (49.0%) patients. White is the predominant race (69.0%), and patients ages were concentrated between 9 and 14 years old (70%). Mucocele was the most frequent (13.5%), followed by dentigerous cyst (6.5%) and fibrous hyperplasia (5.4%). Papilloma and Langerhans cells histiocytosis were the most common non-odontogenic benign and malignant tumors, respectively. In the group of odontogenic tumors, odontoma was the most frequent, and ameloblastoma had a significant incidence (27 cases). These data are important in order to detect differences in geographic areas, diagnosis line tendencies and for clinicians to perform judgment to evaluate of the pediatric patients before the biopsy and management of pediatric oral lesions.

Cottontail rabbit papillomavirus infection in a desert cottontail (Sylvilagus audubonii) from Colorado, USA.

A wild-caught desert cottontail rabbit (Sylvilagus audubonii) from Colorado was observed to have large, pedunculated, dark cutaneous lesions on its abdomen and cylindrical masses on its mouth. Morphologically, the masses were consistent with previous reports of virally induced papillomas. Subsequent DNA analysis indicated widespread infection with cottontail rabbit papillomavirus.

[Epidemiologic study of 147 cases of oral papilloma (Venezuela). 1]. / Estudio epidemiologico de 147 casos de papiloma bucal (Venezuela). Parte I.

A clinical analysis of 147 oral papilloma is presented. Data on age, sex, race, location, clinical appearance, duration, recurrence and multiplicity, and clinical diagnosis are reviewed. The lesions occur over a wide age range, but more than fifty percent were found in patients between 20 to 49 years of age. The data support a slightly higher occurrence rate in females than in males. The tongue was a site of predilection. The other locations that showed a high incidence were the palatal complex, gingiva, lips, respectively. Recurrence rate and incidence of multiple papillomas were low.

Squamous papilloma of the esophagus: long-term follow up.

BACKGROUND AND AIM: Squamous papilloma of the esophagus is a rare benign tumor; less than 200 cases have been reported in the literature. The prevalence of endoscopically diagnosed squamous papilloma of the esophagus has been reported in only a very few series, and varies from 0.01 to 0.43%. Clinical relevance and possible association with other pathological conditions, namely if it is a premalignant lesion, remain a matter of debate. The etiology is controversial, although a role of human papilloma virus has been recently proposed. The aim of this study was to try to determine the prevalence, clinical relevance, possible association with other pathological conditions of the upper digestive tract, and possible etiological role of human papilloma virus on our series of squamous esophageal papillomas. METHODS: Data from a total of 7618 upper gastrointestinal endoscopies consecutively performed in 4 years were obtained. A 4-year follow up was carried out. RESULTS: Squamous esophageal papilloma was found in nine patients (0.01%). The mean size of polyps was 4 mm and the mean distance from the dental ridge was 25 cm. Only one patient had more than one polyp. Two patients had liver cirrhosis and three had peptic ulcer disease. All squamous esophageal papillomas were removed and tested for human papilloma virus with commercial available kits for in situ hybridization, but none was found positive. CONCLUSION: Squamous papilloma of the esophagus is an uncommon disease that does not appear to predispose to esophageal cancer. No association was found with human papilloma virus.

[Prevalence of head and neck lesions at the Technological University of Mexico (UNITEC) 1986-1988]. / Prevalencia de lesiones en cabeza y cuello en la Universidad Technológica de México (UNITEC) 1986-1988.

A prospective study of extra and intraoral biopsies diagnosed and processed at the School of Odontology of the Technological University of Mexico (UNITEC) in its various service units, within a two and a half year period covering from January 1986 to May 1988. Out of 12,456 patients, 73 biopsies and 7 exfoliative cytologies were performed, with 41 different lesions detected. The clinical features of the five conditions most frequently found in the study are emphasized and compared with findings reported in international literature regarding the same lesions.

Oral exophytic lesions in 23,616 white Americans over 35 years of age.

This study provides the first detailed epidemiologic analysis of benign oral soft tissue masses and bony prominences. Of 1,453 such lesions found in 23,616 white persons over 35 years of age, the most common were palatal and mandibular tori, with a combined prevalence rate of 27.1 lesions/1,000 persons. Other lesions commonly found were irritation fibromas (12.0 lesions/1,000 population); hemangiomas (5.5/1,000); papillomas (4.6/1,000); epulides fissurata (4.1/1,000); mucoceles (2.5/1,000); and others. The prevalence of all oral masses was 61.4/1,000 (33.5 if bony lesions are excluded). Sex-specific and site-specific clinical information is offered and is contrasted with the literature.

Changes in the prevalence of HIV-associated mucosal disease at a dedicated clinic over 7 years.

OBJECTIVE: To investigate changes in the prevalence of mucosal disease in patients with HIV/AIDS. DESIGN: Retrospective analysis of clinic database. SETTING: An open-access dental clinic dedicated to the dental treatment of patients infected with HIV in London, UK. SUBJECTS: Dental patients attending for routine assessment (check-up). MAIN OUTCOME MEASURES: Prevalence of HIV associated oral lesions, diagnosed in accordance with EC classification criteria, in patients taking and not taking antiretroviral therapies (ARTs). RESULTS: Data were collected at 2789 dental examinations for 1590 patients between 1992 and 1998. More patients taking ART had one or more oral manifestations in the years up to 1996, after which the prevalence fell to a similar level to those not taking medications. The prevalence of mucosal disease in patients not taking ART was relatively constant over time. These trends were observed for oral hairy leukoplakia, pseudomembranous and erythematous candidiasis and Kaposi's sarcoma but not for oral papillomata. CONCLUSIONS: These data provide evidence that decreases in the prevalence of oral disease in people with HIV infection can be attributed to the effectiveness of ART.

Estudio epidemiológico de 147 casos de papiloma bucal (Venezuela). Parte I / Epidemiologic study of 147 cases of oral papiloma (Venezuela). Part I

Se presenta un análisis clínico de 147 papilomas de la cavidad bucal en donde se destacan los siguientes aspectos: edad, sexo, localización, tamaño, aspecto clínico (forma, color, superficie e implantación), recurrencia y multiplicidad, diagnóstico clínico y motivo de consulta. La lesión se presenta en un rango grande de edades, encontrándose la mayor incidencia entre los 20 y 49 años. Los datos recolectados indican que la lesión es ligeramente más frecuente en el sexo femenino que en el sexo masculino. el mayor número de casos se encontró en la lengua, siguiendo en orden decreciente: paladar, encia y labio. La recurrencia y multiplicidad del papiloma fueron bajas

Pólipo fibro epitelial x papiloma: características histopatológicas e ocorrências (1978-1990) / Fibro-epithelial polyp x papilloma: histopathological characteristics and occurrencies

Os autores realizaram um levantamento dos casos referentes a pólipos fibro-epiteliais e papilomas, no período de 1978-1990, no Departamento de Patologia da Faculdade de Odontologia de Araraquara. Após análise dos resultados, concluíram, entre outras, que os pólipos fibro-epiteliais mostram incidência predominante devendo receber maior atenção e avaliação clínica quanto a fatores etiológicos

Prevalencia de los papilomas en la cavidad bucal producidos por el virus del papiloma humano V.P.H. en niños escolares de Guayaquil 1989-1990 / The prevalence of papillomas in the oral cavity caused by the human papillomavirus H.P.V. in schoolchildren from Guayaquil 1989-1990

El estudio de estos tumores de la cavidad bucal y estructuras adyacentes, constituye una fase importante de la odontología por el papel que desempeña el odontólogo en el diagnóstico y tratamiento de estas lesiones. El papiloma es un tumor que se origina en el tejido epitelial de la mucosa bucal, caracterizado por el aumento del volumen de las papilas. Son clínicamente visibles y fáciles de diagnosticar. En esta investigación se reporta la prevalencia de estas patologías en escolares de Guayaquil, llegándose a determinar una tasa de 13.3 por mil, así como el hallazgo de estas diversas lesiones como: hiperplasia epitelial focal, verrugas vulgares, papilomas simples o múltiples, condiloma acuminado y papiloma laríngeo. Todas estas lesiones etimológicamente se presentan por el "virus del papiloma humano" que fue identificado por primera vez en nuestro país por medio de microscopía electrónica. Existiendo serotipos virales que causan tumores premalignos y malignos