Contribution of the Juxtatransmembrane Intracellular Regions to the Time Course and Permeation of ATP-gated P2X7 Receptor Ion Channels.
Allsopp, Rebecca C; Evans, Richard J.
J Biol Chem
; 290(23): 14556-66, 2015 Jun 05.
Artigo em Inglês | MEDLINE | ID: mdl-25903136
Localization of the gate and selectivity filter of the full-length P2X7 receptor.
Dual gating mechanism and function of P2X7 receptor channels.
A rare P2X7 variant Arg307Gln with absent pore formation function protects against neuroinflammation in multiple sclerosis.
Mapping the Site of Action of Human P2X7 Receptor Antagonists AZ11645373, Brilliant Blue G, KN-62, Calmidazolium, and ZINC58368839 to the Intersubunit Allosteric Pocket.
The P2X7 Receptor.
A consensus segment in the M2 domain of the hP2X(7) receptor shows ion channel activity in planar lipid bilayers and in biological membranes.
The P2X7 receptor as a route for non-exocytotic glutamate release: dependence on the carboxyl tail.
Functional Expression of the P2X7 ATP Receptor Requires Eros.
Mapping the Allosteric Action of Antagonists A740003 and A438079 Reveals a Role for the Left Flipper in Ligand Sensitivity at P2X7 Receptors.
A calcium-sensitive feed-forward loop regulating the expression of the ATP-gated purinergic P2X7 receptor via specificity protein 1 and microRNA-22.