The purinergic receptor P2RX7 directs metabolic fitness of long-lived memory CD8<sup>+</sup> T cells.
Borges da Silva, Henrique; Beura, Lalit K; Wang, Haiguang; Hanse, Eric A; Gore, Reshma; Scott, Milcah C; Walsh, Daniel A; Block, Katharine E; Fonseca, Raissa; Yan, Yan; Hippen, Keli L; Blazar, Bruce R; Masopust, David; Kelekar, Ameeta; Vulchanova, Lucy; Hogquist, Kristin A; Jameson, Stephen C.
; 559(7713): 264-268, 2018 07.
Artigo em Inglês | MEDLINE | ID: mdl-29973721
CD8<sup>+</sup>, but not CD4<sup>+</sup> effector/memory T cells, express the CD44<sup>high</sup>CD45RB<sup>high</sup> phenotype with aging, which displays reduced expression levels of P2X<sub>7</sub> receptor and ATP-induced cellular responses.
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