A peptide of foot-and-mouth disease virus serotype Asia1 generating a neutralizing antibody response, and an immunostimulatory peptide.
Vet Microbiol
; 125(3-4): 224-31, 2007 Dec 15.
Article
en En
| MEDLINE
| ID: mdl-17656048
ABSTRACT
The epitopes of the capsid of foot-and-mouth disease virus (FMDV) play important roles in the construction of highly immunogenic subunit vaccines. However few epitopes have been found for FMDV serotype Asia1. In this study we screened for epitopes of the VP1 and VP2 proteins of FMDV serotype Asia1 isolate, YNBS/58. Fragments consisting of amino acids 133-163 of VP1 and amino acids 1-33 of VP2 contained epitopes, and both induced lymphoproliferation in guinea pigs. Only the VP1 fragment induced neutralizing antibodies but the VP2 peptide dramatically increased the neutralizing antibody response induced by the VP1 peptide.
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Banco de datos:
MEDLINE
Asunto principal:
Inmunización
/
Vacunas de Subunidad
/
Virus de la Fiebre Aftosa
/
Proteínas de la Cápside
/
Fiebre Aftosa
/
Anticuerpos Antivirales
Límite:
Animals
Idioma:
En
Revista:
Vet Microbiol
Año:
2007
Tipo del documento:
Article