Enzyme-catalyzed synthesis of a novel thermosensitive polyester with pendant ketoprofen.
Macromol Biosci
; 11(5): 595-9, 2011 May 12.
Article
en En
| MEDLINE
| ID: mdl-21400661
ABSTRACT
A novel thermosensitive polyester with pendant ketoprofen was synthesized by copolymerization of PEG 800 with 2-ketoprofendimethylmalate using CAL-B at 70 °C. The products were characterized by NMR spectra and GPC. The in vitro study demonstrated that the polyester could release ketoprofen in physiological conditions, which indicates that the polyester could be a promising prodrug.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Poliésteres
/
Portadores de Fármacos
/
Profármacos
/
Cetoprofeno
/
Lipasa
Límite:
Humans
Idioma:
En
Revista:
Macromol Biosci
Asunto de la revista:
BIOQUIMICA
Año:
2011
Tipo del documento:
Article
País de afiliación:
China