Enzyme-catalyzed synthesis of a novel thermosensitive polyester with pendant ketoprofen.

Wang, Hai-Yang; Zhou, Yu-Jie; Wang, Zao; Wang, Na; Li, Kun; Yu, Xiao-Qi

Wang, Hai-Yang; Zhou, Yu-Jie; Wang, Zao; Wang, Na; Li, Kun; Yu, Xiao-Qi.

Afiliación

Wang HY; Key Laboratory of Green Chemistry and Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu, China.

Macromol Biosci ; 11(5): 595-9, 2011 May 12.

Article en En | MEDLINE | ID: mdl-21400661

ABSTRACT

ABSTRACT

A novel thermosensitive polyester with pendant ketoprofen was synthesized by copolymerization of PEG 800 with 2-ketoprofendimethylmalate using CAL-B at 70 °C. The products were characterized by NMR spectra and GPC. The in vitro study demonstrated that the polyester could release ketoprofen in physiological conditions, which indicates that the polyester could be a promising prodrug.

Asunto(s)

Portadores de Fármacos/síntesis química; Cetoprofeno/química; Lipasa/química; Poliésteres/síntesis química; Profármacos/síntesis química; Candida/enzimología; Preparaciones de Acción Retardada; Humanos; Hidrólisis; Polietilenglicoles/química; Temperatura de Transición

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Poliésteres / Portadores de Fármacos / Profármacos / Cetoprofeno / Lipasa Límite: Humans Idioma: En Revista: Macromol Biosci Asunto de la revista: BIOQUIMICA Año: 2011 Tipo del documento: Article País de afiliación: China

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