A polymer coating applied to Salmonella prevents the binding of Salmonella-specific antibodies.
Int J Cancer
; 132(3): 717-25, 2013 Feb 01.
Article
en En
| MEDLINE
| ID: mdl-22736433
ABSTRACT
The use of Salmonella as a potential antitumor agent has been investigated, but innate immunity against this bacterium reduces the efficacy of its tumor-targeting and antitumor activities. The purpose of this study was to investigate the modulation of the tumor-targeting efficiency of Salmonella enterica serovar choleraesuis by modifying the immune response to these bacteria by coating them with poly(allylamine hydrochloride) (PAH), designated PAH-S.C. To evaluate this modulation, we used naïve mice and mice immunized with Salmonella to study the role of the preexisting immune response to the antitumor activity of PAH-S.C. When anti-Salmonella antibodies were present, the invasion activity, cytotoxicity, and gene transfer of Salmonella was significantly decreased, both in vitro and in vivo. Treatment with PAH-S.C. resulted in delayed tumor growth and enhanced survival in immunized mice. Furthermore, immunohistochemical studies of the tumors revealed the infiltration of neutrophils and macrophages in immunized mice treated with PAH-S.C. These results indicate that Salmonella encapsulation effectively circumvented the Salmonella-specific immune response.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Salmonella enterica
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Macrófagos
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Anticuerpos Antibacterianos
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Neoplasias Experimentales
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Neutrófilos
Límite:
Animals
Idioma:
En
Revista:
Int J Cancer
Año:
2013
Tipo del documento:
Article
País de afiliación:
Taiwán