In vivo pressure sore-healing efficacy of ß-cyclodextrin/polyethyleneimine/silk fibroin xerogel.
Int J Dermatol
; 51(8): 987-95, 2012 Aug.
Article
en En
| MEDLINE
| ID: mdl-22788820
ABSTRACT
BACKGROUND:
ß-Cyclodextrin (ßCD) xerogel containing silk fibroin (SF) was prepared, and the efficacy of the xerogel for a pressure sore developed on the back of an ICR mouse was investigated. MATERIALS ANDMETHODS:
Tosyl ßCD was conjugated to polyethyleneimine (PEI), and the ßCD residues were cross-linked in an aqueous phase using epichlorohydrin as a cross-linker in the presence of SF. The xerogel composed of ßCD, PEI, and SF (ßCD/PEI/SF xerogel) was prepared by freeze drying the hydrogel. The in vivo pressure sore-healing efficacy of the xerogel was estimated through the skin appearance, skin thickness, hyperplasia of the epidermis, and number of neutrophils in the skin tissue.RESULTS:
The animal group treated with ßCD/PEI/SF xerogels showed a better sore-healing efficacy than the group without treatment and the group treated with over-the-counter products through the determination of the reduction of hyperplasia of the epidermis and the number of neutrophils in skin tissue. We also got the same result by macroscopic evaluation.CONCLUSIONS:
ßCD/PEI/SF xerogel exhibited a high wound-healing efficacy for pressure sores developed on the back of an ICR mouse and left no scar.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Polietileneimina
/
Hidrogel de Polietilenoglicol-Dimetacrilato
/
Úlcera por Presión
/
Beta-Ciclodextrinas
/
Fibroínas
Límite:
Animals
Idioma:
En
Revista:
Int J Dermatol
Año:
2012
Tipo del documento:
Article