Salivary proteomics in biomedical research.
Clin Chim Acta
; 415: 261-5, 2013 Jan 16.
Article
en En
| MEDLINE
| ID: mdl-23146870
ABSTRACT
Proteins that are important indicators of physiological or pathological states, can provide information for the identification of early and differential markers for disease. Saliva, contains an abundance of proteins, offers an easy, inexpensive, safe, and non-invasive approach for disease detection, and possesses a high potential to revolutionize the diagnostics. Discovery of salivary biomarkers could be used to scrutinize health and disease surveillance. The impact of human saliva proteome analysis in the search for clinically relevant disease biomarkers will be realized through advances made using proteomic technologies. The advancements of emerging proteomic techniques have benefited biomarker research to the point where saliva is now recognized as an excellent diagnostic medium for the detection of disease. This review presents an overview of the value of saliva as a credible diagnostic tool and we aim to summarize the proteomic technologies currently used for global analysis of saliva proteins and to elaborate on the application of saliva proteomics to the discovery of disease biomarkers, and discuss some of the critical challenges and perspectives in this field.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Saliva
/
Proteínas y Péptidos Salivales
/
Proteoma
/
Proteómica
/
Investigación Biomédica
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
Clin Chim Acta
Año:
2013
Tipo del documento:
Article
País de afiliación:
China