Histopathologic and Histomorphometric Analysis of Irradiation Injury in Bone and the Surrounding Soft Tissues of the Jaws.
J Oral Maxillofac Surg
; 74(1): 190-9, 2016 Jan.
Article
en En
| MEDLINE
| ID: mdl-26253013
ABSTRACT
PURPOSE:
Surgery of irradiated tissue has an increased complication rate because of the development of hypovascular, hypocellular, and hypoxic tissue. This study was undertaken to perform histopathologic and histomorphometric analyses of irradiation tissue injury in bone and the surrounding soft tissues. MATERIAL ANDMETHODS:
The histopathologic findings of 40 human mandibular bones and the surrounding soft tissue specimens obtained from different patients who underwent surgical procedures for treatment of osteoradionecrosis of the jaws were reviewed.RESULTS:
Histopathologic examination showed 7 processes in the following order of appearance hyperemia, endarteritis, thrombosis, cell loss, hypovascularity, increase of fat in the bone marrow cavity, and fibrosis. Histomorphometric analysis showed significant hypocellularity (P = .007), hypovascularity (P < .001), and fibrosis (P < .001) in irradiated specimens compared with control specimens.CONCLUSION:
These results showed that radiation injuries affect the bone and surrounding soft tissues. However, the irradiation-induced injuries, such as cellular loss (hypocellularity) and fibrosis, were more expressive in bone tissue than in the surrounding soft tissues.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Osteorradionecrosis
/
Periodoncio
/
Enfermedades Mandibulares
Límite:
Humans
Idioma:
En
Revista:
J Oral Maxillofac Surg
Año:
2016
Tipo del documento:
Article
País de afiliación:
Brasil