Determination of metoprolol enantiomers in human plasma and saliva samples utilizing microextraction by packed sorbent and liquid chromatography-tandem mass spectrometry.

Elmongy, Hatem; Ahmed, Hytham; Wahbi, Abdel-Aziz; Amini, Ahmad; Colmsjö, Anders; Abdel-Rehim, Mohamed

Elmongy, Hatem; Ahmed, Hytham; Wahbi, Abdel-Aziz; Amini, Ahmad; Colmsjö, Anders; Abdel-Rehim, Mohamed.

Afiliación

Elmongy H; Department of Environmental Science and Analytical Chemistry, Stockholm University, SE10691, Stockholm, Sweden.
Ahmed H; Pharmaceutical Analysis Department, Faculty of Pharmacy, Damanhour University, Damanhour, 22511, Egypt.
Wahbi AA; Pharmaceutical Analysis Department, Faculty of Pharmacy, Damanhour University, Damanhour, 22511, Egypt.
Amini A; Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, University of Alexandria, Alexandria, 21521, Egypt.
Colmsjö A; Swedish Drug Agency, Uppsala, Sweden.
Abdel-Rehim M; Department of Environmental Science and Analytical Chemistry, Stockholm University, SE10691, Stockholm, Sweden.

Biomed Chromatogr ; 30(8): 1309-17, 2016 Aug.

Article en En | MEDLINE | ID: mdl-26766521

Asunto(s)

Antagonistas Adrenérgicos beta/metabolismo; Cromatografía Liquida/métodos; Metoprolol/metabolismo; Saliva/metabolismo; Espectrometría de Masas en Tándem/métodos; Antagonistas Adrenérgicos beta/sangre; Humanos; Límite de Detección; Metoprolol/sangre; Reproducibilidad de los Resultados; Estereoisomerismo

Palabras clave

chiral chromatography; metoprolol enantiomers; plasma; saliva; tandem mass spectrometry; therapeutic drug monitoring

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Saliva / Cromatografía Liquida / Antagonistas Adrenérgicos beta / Espectrometría de Masas en Tándem / Metoprolol Límite: Humans Idioma: En Revista: Biomed Chromatogr Año: 2016 Tipo del documento: Article País de afiliación: Suecia

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