Two-Photon Lithographic Patterning of DNA-Coated Single-Microparticle Surfaces.
Nano Lett
; 19(1): 618-625, 2019 01 09.
Article
en En
| MEDLINE
| ID: mdl-30585496
ABSTRACT
The spatially defined functionalization of microparticles with asymmetric shape-controlled nucleic acid patterns is a major challenge in materials science. The asymmetric patterning of microparticles is important to allow the controlled fabrication of crystalline lattices or controlled aggregates of microparticles. We present the combination of two-photon lithography and photocleavable o-nitrobenzylphosphate ester nucleic acid coating-modified microparticles as a versatile means to asymmetrically pattern single microparticle surfaces. The two-photon patterning of microparticles with predesigned nucleic acid structures of different sizes (700 nm to 2.8 µm) and shapes (circles, rings, triangles, and squares) are demonstrated. In addition, complex patterned domains consisting of two different asymmetric nucleic acid domains are fabricated by the controlled Z-positioning of the microparticles in respect to the two-photon irradiation sources. In addition, the two-photon lithographic patterning of the photocleavable DNA coating allows the generation of functional nucleic acid domains for the photostimulated activation of the catalytic hybridization assembly (CHA) of branched nucleic acid structures on single microparticles.
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Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
ADN
/
Materiales Biocompatibles Revestidos
/
Nanotecnología
Idioma:
En
Revista:
Nano Lett
Año:
2019
Tipo del documento:
Article
País de afiliación:
China