Two new xanthones, a new lignin, and twenty phenolic compounds from Smilax china and their NO production inhibitory activities.
J Asian Nat Prod Res
; 22(6): 509-520, 2020 Jun.
Article
en En
| MEDLINE
| ID: mdl-30963782
ABSTRACT
Two new xanthones smilone A (1), smilone B (2), and a new lignin smilgnin A (3) were isolated from the rhizomes of Smilax china L., together with three known xanthones (4-6), four lignins (7-10), two flavones (11, 12), two stilbenoids (13, 14), and ten organic phenoloids (15-24). Of them, compounds 4-6 were isolated from the genus Smilax for the first time. The structures of 1-24 were elucidated by the extensive analysis of spectral data and compared with the literature. All compounds were evaluated for their inhibitory effects against LPS-induced NO production in RAW264.7 macrophages. Among them, compound 24 exhibited significant inhibitory activity against NO production (IC50 = 1.26 µM), while compounds 3, 6, and 7 showed weak activities at the concentration of 50 µM.[Formula see text].
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Smilax
/
Xantonas
País/Región como asunto:
Asia
Idioma:
En
Revista:
J Asian Nat Prod Res
Asunto de la revista:
BOTANICA
/
QUIMICA
Año:
2020
Tipo del documento:
Article
País de afiliación:
China