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Donut-like MOFs of copper/nicotinic acid and composite hydrogels with superior bioactivity for rh-bFGF delivering and skin wound healing.
Wang, Tian-Long; Zhou, Zi-Fei; Liu, Jun-Feng; Hou, Xiao-Dong; Zhou, Zhi; Dai, Yun-Lu; Hou, Zhi-Yong; Chen, Feng; Zheng, Long-Po.
Afiliación
  • Wang TL; Department of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, 200072, Shanghai, China.
  • Zhou ZF; Department of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, 200072, Shanghai, China.
  • Liu JF; Shanghai Trauma Emergency Center, Shanghai, 200072, China.
  • Hou XD; Department of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, 200072, Shanghai, China.
  • Zhou Z; Department of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, 200072, Shanghai, China.
  • Dai YL; Department of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, 200072, Shanghai, China.
  • Hou ZY; Cancer Centre, Faculty of Health Sciences, University of Macau, 999078, Macau SAR, China.
  • Chen F; Department of Orthopaedic Surgery, Third Hospital of Hebei Medical University, Shijiazhuang, 050051, China. drzyhou@gmail.com.
  • Zheng LP; Department of Orthopedics, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, 200072, Shanghai, China. fchen@tongji.edu.cn.
J Nanobiotechnology ; 19(1): 275, 2021 Sep 09.
Article en En | MEDLINE | ID: mdl-34503490
BACKGROUND: Skin injury and the resultant defects are common clinical problems, and usually lead to chronic skin ulcers and even life-threatening diseases. Copper, an essential trace element of human body, has been reported to promote the regeneration of skin by stimulating proliferation of endothelial cell and enhance angiogenesis. RESULTS: Herein, we have prepared a new donut-like metal-organic frameworks (MOF) of copper-nicotinic acid (CuNA) by a simple solvothermal reaction. The rough surface of CuNA is beneficial for loading/release basic fibroblast growth factor (bFGF). The CuNAs with/without bFGF are easily processed into a light-responsive composite hydrogel with GelMA, which not only show excellent mechanical properties, but also display superior biocompatibility, antibacterial ability and bioactivity. Moreover, in the in vivo full-thickness defect model of skin wound, the resultant CuNA-bFGF@GelMA hydrogels significantly accelerate the wound healing, by simultaneously inhibiting the inflammatory response, promoting the new blood vessels formation and the deposition of collagen and elastic fibers. CONCLUSIONS: Considering the superior biocompatibility, antibacterial ability and bioactivity, the CuNA and its composite light-responsive hydrogel system will be promising in the applications of skin and even other tissue regeneration.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Piel / Cicatrización de Heridas / Factor 2 de Crecimiento de Fibroblastos / Hidrogeles / Estructuras Metalorgánicas Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: J Nanobiotechnology Año: 2021 Tipo del documento: Article País de afiliación: China

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Piel / Cicatrización de Heridas / Factor 2 de Crecimiento de Fibroblastos / Hidrogeles / Estructuras Metalorgánicas Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: J Nanobiotechnology Año: 2021 Tipo del documento: Article País de afiliación: China