Effects of SNPs in SOD2 and SOD3 interacted with fluoride exposure on the susceptibility of dental fluorosis.
Int J Hyg Environ Health
; 239: 113879, 2022 01.
Article
en En
| MEDLINE
| ID: mdl-34758947
ABSTRACT
A total of 649 children aged 7-13 years of age were recruited in a cross-sectional study in Tongxu County, China (2017) to assess the effects of interaction between single nucleotide polymorphisms (SNPs) in SOD2 and SOD3 gene and fluoride exposure on dental fluorosis (DF) status. Associations between biomarkers and DF status were evaluated. Logistic regression suggested that the risk of DF in children with rs10370 GG genotype and rs5746136 TT genotype was 1.89-fold and 1.72-fold than that in children with TT/CC genotype, respectively. Increased T-SOD activity was associated with a lower risk of DF (OR = 0.99). The rs2855262*rs10370*UF model was regarded as the optimal interaction model in generalized multifactor dimensionality reduction analyses. Our findings suggested that rs4880 and rs10370 might be useful genetic markers for DF, and there might be interactions among rs10370 in SOD2, rs2855262 in SOD3, and fluoride exposure on DF status.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Superóxido Dismutasa
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Polimorfismo de Nucleótido Simple
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Fluorosis Dental
Tipo de estudio:
Observational_studies
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Prevalence_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Adolescent
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Child
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Humans
País/Región como asunto:
Asia
Idioma:
En
Revista:
Int J Hyg Environ Health
Asunto de la revista:
SAUDE AMBIENTAL
/
SAUDE PUBLICA
Año:
2022
Tipo del documento:
Article