Roles of exosomes in regenerative periodontology: a narrative review.
Mol Biol Rep
; 49(12): 12219-12225, 2022 Dec.
Article
en En
| MEDLINE
| ID: mdl-36266554
ABSTRACT
Periodontitis is the primary cause of irreversible destruction of the periodontium surrounding teeth. Proinflammatory cytokines are secreted by pathogens in the biofilm and destroy the periodontium. Exosomes released into all biological fluids from saliva have enabled many innovations in the early diagnosis and treatment of periodontal diseases. This narrative review describes the role of exosomes in various diseases, and their involvement in periodontal diseases and periodontal regeneration primarily. Since guided tissue regeneration offers unpredictable results that vary according to the case, new developments in periodontal treatment are needed. Exosomes are suitable drug carriers for periodontal regeneration due to their isolation from every biological fluid, biocompatibility, low toxicity and high concentration of drugs reaching the target tissue. Exosomes obtained from mesenchymal stem cells can be used for periodontal regeneration in periodontal flaps, scaffolds, or periodontal defect areas through biomaterials such as drugs and hydrogels. Exosomes are significant in the early diagnosis and development of treatment of many diseases such as cardiovascular, neurodegenerative, diabetes and prognostic markers in cancer. Future studies are needed to elucidate the effects and possible mechanisms of exosomes in periodontitis and periodontal diseases and other systemic diseases, as they have many promises in diagnosis, treatment, and prognosis.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Enfermedades Periodontales
/
Periodontitis
/
Exosomas
Tipo de estudio:
Screening_studies
Límite:
Humans
Idioma:
En
Revista:
Mol Biol Rep
Año:
2022
Tipo del documento:
Article
País de afiliación:
Chipre