Effectiveness of curcumin-based antimicrobial photodynamic therapy against Staphylococcus aureus.
J Oral Sci
; 65(4): 270-274, 2023.
Article
en En
| MEDLINE
| ID: mdl-37778986
ABSTRACT
PURPOSE:
This study investigated the effectiveness of curcumin-based antimicrobial photodynamic therapy (aPDT) against Staphylococcus aureus (S. aureus), the causative agent of ventilator-associated pneumonia.METHODS:
Curcumin was added to S. aureus culture medium at concentrations of 25, 2.5, and 0.25 µM. After 60 min (20-25°C), each culture was irradiated for 1 and 3 min, and viable bacteria were counted. Curcumin (25 µM) was also added to a bacterial suspension with D-mannitol and sodium azide; microbial counts were determined after irradiation for 3 min.RESULTS:
S. aureus was significantly reduced in the 1-min (P = 0.043) and 3-min (P = 0.011) irradiation groups in comparison to the 0-min irradiation group with 25 µM curcumin. No significant differences were observed between the curcumin alone group and the curcumin plus D-mannitol or sodium azide group.CONCLUSION:
The findings of this study indicate that prolonged exposure (≥1 min) of S. aureus to LED in 25 µM curcumin solution induces cell wall injury. Curcumin-based aPDT as an adjunct to conventional oral care, employing existing dentistry equipment, offers a promising approach that does not rely on antimicrobial drugs or allows the emergence of resistant bacterial strains. This suggests its potential role in future strategies aimed at preventing ventilator-associated pneumonia.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Fotoquimioterapia
/
Curcumina
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Neumonía Asociada al Ventilador
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Antiinfecciosos
Límite:
Humans
Idioma:
En
Revista:
J Oral Sci
Asunto de la revista:
ODONTOLOGIA
Año:
2023
Tipo del documento:
Article