Phosphatidic acid as a calcium ionophore in large unilamellar vesicle systems.
Biochim Biophys Acta
; 777(2): 343-6, 1984 Nov 07.
Article
en En
| MEDLINE
| ID: mdl-6435674
ABSTRACT
The ionophoretic capabilities of dioleoylphosphatidic acid (DOPA) for transporting calcium across phospholipid bilayers have been investigated. Calcium uptake by large unilamellar vesicles is shown to depend on the presence of DOPA. This uptake is sensitive to the nature and concentration of calcium chelators in the vesicle interior, indicating that accumulation results from DOPA-mediated translocation of calcium across the membrane. Further, it is shown that characteristics of DOPA-mediated Ca2+ uptake are similar to those observed for the fungal calcium ionophore, A23187.
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Banco de datos:
MEDLINE
Asunto principal:
Ácidos Fosfatidicos
/
Calcio
/
Ionóforos
/
Liposomas
Idioma:
En
Revista:
Biochim Biophys Acta
Año:
1984
Tipo del documento:
Article