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Comparison of amitriptyline supplemented with pregabalin, pregabalin supplemented with amitriptyline, and duloxetine supplemented with pregabalin for the treatment of diabetic peripheral neuropathic pain (OPTION-DM): a multicentre, double-blind, randomised crossover trial.
Tesfaye, Solomon; Sloan, Gordon; Petrie, Jennifer; White, David; Bradburn, Mike; Julious, Stephen; Rajbhandari, Satyan; Sharma, Sanjeev; Rayman, Gerry; Gouni, Ravikanth; Alam, Uazman; Cooper, Cindy; Loban, Amanda; Sutherland, Katie; Glover, Rachel; Waterhouse, Simon; Turton, Emily; Horspool, Michelle; Gandhi, Rajiv; Maguire, Deirdre; Jude, Edward B; Ahmed, Syed H; Vas, Prashanth; Hariman, Christian; McDougall, Claire; Devers, Marion; Tsatlidis, Vasileios; Johnson, Martin; Rice, Andrew S C; Bouhassira, Didier; Bennett, David L; Selvarajah, Dinesh.
Affiliation
  • Tesfaye S; Diabetes Research Unit, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK; School of Health and Related Research, and Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK. Electronic address: solomon.tesfaye@nhs.net.
  • Sloan G; Diabetes Research Unit, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.
  • Petrie J; Clinical Trials Research Unit, University of Sheffield, Sheffield, UK.
  • White D; Clinical Trials Research Unit, University of Sheffield, Sheffield, UK.
  • Bradburn M; Clinical Trials Research Unit, University of Sheffield, Sheffield, UK.
  • Julious S; Medical Statistics Group, University of Sheffield, Sheffield, UK.
  • Rajbhandari S; Department of Diabetes, Lancashire Teaching Hospitals NHS Trust, Chorley, UK.
  • Sharma S; Diabetes and Endocrine Centre, East Suffolk and North Essex NHS Foundation Trust, Ipswich, UK.
  • Rayman G; Diabetes and Endocrine Centre, East Suffolk and North Essex NHS Foundation Trust, Ipswich, UK.
  • Gouni R; Diabetes and Endocrine Centre, Nottingham University Hospitals NHS Trust, Nottingham, UK.
  • Alam U; Department of Cardiovascular & Metabolic Medicine, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, UK; Liverpool University Hospital NHS Foundation Trust, Liverpool, UK.
  • Cooper C; Clinical Trials Research Unit, University of Sheffield, Sheffield, UK.
  • Loban A; Clinical Trials Research Unit, University of Sheffield, Sheffield, UK.
  • Sutherland K; Clinical Trials Research Unit, University of Sheffield, Sheffield, UK.
  • Glover R; Clinical Trials Research Unit, University of Sheffield, Sheffield, UK.
  • Waterhouse S; Clinical Trials Research Unit, University of Sheffield, Sheffield, UK.
  • Turton E; Clinical Trials Research Unit, University of Sheffield, Sheffield, UK.
  • Horspool M; NHS Sheffield Clinical Commissioning Group, Sheffield, UK.
  • Gandhi R; Diabetes Research Unit, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.
  • Maguire D; Department of Diabetes and Endocrinology, Harrogate and District NHS Foundation Trust, Harrogate, UK.
  • Jude EB; Department of Diabetes and Endocrinology, Tameside and Glossop Integrated Care NHS Foundation Trust, Ashton under Lyne, UK; Division of Diabetes, Endocrinology & Gastroenterology, University of Manchester, Manchester, UK.
  • Ahmed SH; School of Medicine, University of Liverpool, Liverpool, UK; Department of Diabetes and Endocrinology, Countess of Chester Hospital NHS Foundation Trust, Chester, UK.
  • Vas P; Department of Diabetes, King's College Hospital NHS Foundation Trust, London, UK.
  • Hariman C; Department of Diabetes and Endocrinology, The Royal Wolverhampton NHS Trust, Wolverhampton, UK.
  • McDougall C; Department of Medicine, University Hospital Hairmyres, NHS Lanarkshire, Hairmyres, UK.
  • Devers M; Department of Diabetes, University Hospital Monklands, NHS Lanarkshire, Monklands, UK.
  • Tsatlidis V; Department of Endocrinology and Diabetes, Gateshead Health NHS Foundation Trust, Gateshead, UK.
  • Johnson M; St Pancras Clinical Research, London, UK.
  • Rice ASC; Pain Research, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, UK.
  • Bouhassira D; Inserm U987, APHP, UVSQ, Paris-Saclay University, Paris, France.
  • Bennett DL; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
  • Selvarajah D; School of Health and Related Research, and Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK.
Lancet ; 400(10353): 680-690, 2022 08 27.
Article in En | MEDLINE | ID: mdl-36007534
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Full text: 1 Database: MEDLINE Main subject: Diabetes Mellitus / Diabetic Neuropathies / Neuralgia Type of study: Clinical_trials / Guideline / Health_technology_assessment / Prognostic_studies Limits: Humans Language: En Journal: Lancet Year: 2022 Type: Article
Fulltext
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Full text: 1 Database: MEDLINE Main subject: Diabetes Mellitus / Diabetic Neuropathies / Neuralgia Type of study: Clinical_trials / Guideline / Health_technology_assessment / Prognostic_studies Limits: Humans Language: En Journal: Lancet Year: 2022 Type: Article