Pain and salivary biomarkers of stress in temperomandibular disorders were affected by maxillary splints.
J Oral Rehabil
; 51(6): 1025-1033, 2024 Jun.
Article
in En
| MEDLINE
| ID: mdl-38475974
ABSTRACT
BACKGROUND:
Longitudinal intervention studies on treatment options in temporomandibular dysfunction (TMD) including self reports and salivary biomarkers of stress are rare and the exact therapeutic function of occlusal splints widely unknown.METHODS:
We examined the therapeutic effects of a Michigan splint with occlusal relevance in patients with TMD using a placebo-controlled, delayed-start design. Two intervention groups received a Michigan splint, while one of them had a placebo palatine splint for the first 3 weeks. We collected pain intensities (at rest and after five occlusal movements), salivary measures associated with stress (cortisol and alpha-amylase) and self-reported psychological distress (stress, anxiety, catastrophizing) at baseline and 3 and 7 weeks after onset of intervention.RESULTS:
At baseline, we observed increased pain intensity and psychological distress in TMD patients compared to 11 matched healthy controls. Baseline anxiety was linked to movement pain intensity through stress. Over therapy reductions in pain intensity and morning cortisol were more pronounced in those patients starting immediately with the Michigan splint, while psychological distress decreased similarly in both groups.CONCLUSION:
Our results suggest that perceived stress plays a role for the association between anxiety and TMD pain and underlines the need for an interdisciplinary perspective on the pathogenesis and therapy of TMD in a setting where psychotherapeutic knowledge is still scarce or rarely applied.Key words
Full text:
1
Database:
MEDLINE
Main subject:
Saliva
/
Stress, Psychological
/
Pain Measurement
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Hydrocortisone
/
Biomarkers
/
Temporomandibular Joint Disorders
/
Occlusal Splints
Limits:
Adult
/
Female
/
Humans
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Male
/
Middle aged
Language:
En
Journal:
J Oral Rehabil
/
J. oral rehabil
/
Journal of oral rehabilitation
Year:
2024
Type:
Article
Affiliation country: