Late Diagnosis of Oral Melanoma / Diagnóstico Tardío de Melanoma Oral
Santana, Lucas Alves da Mota; Cunha, John Lennon Silva; Ribeiro, Thiago Santana; Sánchez-Romero, Celeste; Trento, Cleverson Luciano; Marqueti, Antônio Carlos; de Albuquerque-Júnior, Ricardo Luiz Cavalcanti; Sousa, Sílvia Ferreira de.
Int. j. odontostomatol. (Print)
; 13(2): 230-234, jun. 2019. graf
Artigo
em Inglês
| LILACS | ID: biblio-1002310
ABSTRACT: Oral melanoma (OM) is an extremely rare and aggressive malignancy. A 67-year-old patient presented with complains of a slightly symptomatic spot in the mouth since the past 2 years. Extraoral examination revealed left cervical lymphadenopathy, and intraoral examination a blue-black multinodular sessile mass, with irregular margins, involving the attached gingiva of teeth 27 and 28, extending to vestibular sulcus and hard palate, measuring approximately 3.5 cm. The lesion presented focal areas of ulceration. Panoramic radiograph did not show bone involvement. The main diagnostic hypothesis was oral melanoma. Microscopic findings of the incisional biopsy revealed a proliferation of densely pigmented pleomorphic cells, invading the subepithelial connective tissue in sheets or nests showing an organoid pattern. Immunopositivity for S-100, Melan-A and HMB-45 confirmed the diagnosis of melanoma. The patient was referred to an oncology hospital in which multiple metastases were detected, and the patient was subjected to palliative care. Herein we report an OM in advanced clinical stage, and discuss the clinical, morphological and immunohistochemical diagnostic criteria with emphasis on the importance of early diagnosis.
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