Abstract
Acetaldehyde , associated with
consumption of
alcoholic beverages , is known to be a
carcinogen and to be related to the
tongue dorsum. Objective The aim of this study was to investigate the relationship between
acetaldehyde concentration in
mouth air and bacterial characteristics on the
tongue dorsum.
Methodology Thirty-nine
healthy volunteers participated in the study.
Acetaldehyde concentrations in
mouth air were evaluated by a high-
sensitivity semiconductor gas sensor. A
16S rRNA gene sequencing
technique was used to compare
microbiomes between two groups, focusing on the six samples with the highest
acetaldehyde concentrations (HG) and the six samples with lowest
acetaldehyde concentrations (LG). Results
Acetaldehyde concentration increased in correlation with the increase in
bacterial count (p=0.048). The number of species observed in the oral
microbiome of the HG was higher than that in the oral
microbiome of the LG (p=0.011). The relative abundances of
Gemella sanguinis,
Veillonella parvula and
Neisseria flavescens in the oral
microbiome of the HG were higher than those in the oral
microbiome of the LG (p<0.05). Conclusion
Acetaldehyde concentration in
mouth air was associated with
bacterial count , diversity of
microbiome , and relative abundance of G. sanguinis, V. parvula, and N. flavescens.