Multivariate analysis of risk factors for neck metastases in surgically treated parotid carcinomas / Análise multivariada de fatores de risco para metástase de pescoço em cirurgicamente tratadas carcinomas parótidas

ABSTRACT

Objective: To analyze risk factors for neck metastases in patients with parotid carcinomas. Design: Cohort of patients followed up from 1 to 366.2 months at a single institution Setting: Referral center, private or institutional practice, hospitalized care. Patients A total of 145 patients with parotid carcinomas with complete clinical and pathological information. The histological diagnosis was reviewed according to the Word Health Organization classification for salivary gland tumors. Intervention Patients were treated by surgery alone (62 cases) or with postoperative radiotherapy (83 cases). A neck dissection was performed in 80 patients. Main Outcome Measure: Rates of neck lymph node metastasis. Univariate and multivariate analyses were caried out using logistic regression evaluating the significance of demographic, clinical, and pathological data. Results: The following variables were significantly associated to the risk of lymph mode metastasis by univariate analysis: histological type (P<.001), facial palsy (P=.02), perineural invasion (P=.01), extraparotid tumor extension (P=.02) and necrosis (P=.003). By multivariate analysis, histological type (P<.001), T stage (P=.03), and desmoplasia (P=.006) had the highest correlation with lymph node metastasis. Conclusion: The significant risk factors for neck metastasis in parotid carcinoma were histological type (ie, adenocarcinoma, undifferentiated carcinoma, high-grade mucoepidermoid carcinoma, squamous cell carcinoma, and salivary duct carcinoma), T stage (T3 and T4), and desmoplasia (severe)