Rapid improvement of icterus and pruritus by the oral administration of colestimide in two cases of drug-induced hepatitis.
Intern Med
; 40(11): 1098-103, 2001 Nov.
Article
em En
| MEDLINE
| ID: mdl-11757763
ABSTRACT
We report two cases of drug-induced hepatitis refractory to therapy of ursodeoxycholic acid and prednisolone, who were relieved of icterus and pruritus immediately by the oral administration of colestimide. Their liver dysfunction was not improved, by withdrawal of causative drugs or by treatment with prednisolone and ursodeoxycholic acid. Colestimide (3.0 g/day), a strong basic anion-exchange resin, was orally taken before breakfast and evening meal, leading to rapid and complete relief of icterus and pruritus. These cases suggested that colestimide would be useful for patients with cholestasis in drug-induced hepatitis, because this agent has few side effects and it is easy to take.
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Base de dados:
MEDLINE
Assunto principal:
Prurido
/
Colestase Intra-Hepática
/
Doença Hepática Induzida por Substâncias e Drogas
/
Resinas de Troca Aniônica
/
Antídotos
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Intern Med
Assunto da revista:
MEDICINA INTERNA
Ano de publicação:
2001
Tipo de documento:
Article