Antigenotoxic potential of certain dietary constituents.
Teratog Carcinog Mutagen
; Suppl 1: 323-35, 2003.
Article
em En
| MEDLINE
| ID: mdl-12616623
ABSTRACT
The human diet contains a variety of compounds that exhibit chemopreventive effects towards an array of xenobiotics. In the present study, the antigenotoxic potential of selected dietary constituents including Diallyl sulfide (DAS), Indole-3-carbinol (I3C), Curcumin (CUR), and Black tea polyphenols (BTP) has been evaluated in the Salmonella typhimurium reverse mutation and mammalian in vivo cytogenetic assays. In addition, the anticlastogenic effect of the above dietary constituents was identified towards Benzo(a)pyrene (BaP) and cyclophosphamide- (CP) induced cytogenetic damage in mouse bone marrow cells. The induction of BaP and CP induced chromosomal aberrations, micronuclei formation, and sister chromatid exchanges (SCEs) were found to be inhibited in a dose-dependent manner by DAS, I3C, CUR, and BTP. Thus the study reveals the antimutagenic potential of these dietary compounds towards BaP- and CP-induced genotoxicity in microbial and mammalian test systems.
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Base de dados:
MEDLINE
Assunto principal:
Flavonoides
/
Dieta
Limite:
Animals
Idioma:
En
Revista:
Teratog Carcinog Mutagen
Ano de publicação:
2003
Tipo de documento:
Article
País de afiliação:
Índia