Expression pattern of NOGO and NgR genes during human development.
Gene Expr Patterns
; 5(4): 561-8, 2005 Apr.
Article
em En
| MEDLINE
| ID: mdl-15749087
ABSTRACT
Nogo protein has been identified as the component of central nervous system (CNS) myelin that limits axonal regeneration. We investigated the expression of the genes encoding Nogo and its receptor, NgR, between weeks eight and 23 of human embryonic development, by quantitative radioactive in situ hybridization. At 8 weeks, we detected NOGO and NgR transcripts in developing neuronal and non-neuronal structures. We focused on two different structures the brain and the dental germs. During this period of development, NOGO and NgR transcripts colocalized in the cortical and ventricular zones of the brain, with expression strongest for these two genes in the postmitotic cells of the cortical plate. In developing dental germs, NgR was more strongly expressed than NOGO at 16 and 21 weeks. NOGO and NgR were expressed in zones of epithelium-mesenchyme interaction, which induce the differentiation of ameloblasts/odontoblasts. These genes were expressed most strongly in differentiated cells.
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Base de dados:
MEDLINE
Assunto principal:
Encéfalo
/
Receptores de Superfície Celular
/
Regulação da Expressão Gênica no Desenvolvimento
/
Proteínas da Mielina
Limite:
Humans
Idioma:
En
Revista:
Gene Expr Patterns
Assunto da revista:
BIOLOGIA MOLECULAR
/
CEREBRO
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
França