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A tetra(L-lysine)-grafted poly(organophosphazene) for gene delivery.

Jun, Yong Joo; Kim, Jung Hee; Choi, Su Jin; Lee, Hwa Jeong; Jun, Moo Jin; Sohn, Youn Soo.
Bioorg Med Chem Lett; 17(11): 2975-8, 2007 Jun 01.
Artigo em Inglês | MEDLINE | ID: mdl-17428658
In order to develop a new gene delivery vector, a novel cationic poly(organophosphazene) was synthesized by stepwise nucleophilic substitutions of poly(dichlorophosphazene) with a hydrophilic methoxy-poly(ethylene glycol) (MPEG) as a shielding group and a branched tetra(L-lysine), LysLys(LysEt)(2), as a cationic moiety. The cationic polymer has shown to form a polyplex by DNA condensation and very low in vitro cytotoxicity probably due to the shielding effect of MPEG, which provides a basis for improving the low gene transfection yield of cationic polyphosphazenes.