[Optimization of matrix formulation of effective parts cataplasm of Pogostemon cablin by uniform design].

ABSTRACT

OBJECTIVE: To optimize the matrix formulation of the effective part Cataplasm of Pogostemon Cablin. METHOD: The optimal preparation prescription was selected by U17 (17(11)) uniform design,and the tacking strength, cohesive strength and transdermal speed constant were used as test indexes. The equations of three test indexes were established by SPSS. With analysis of the contribution of factors by SPSS regression, the optimal matrix formulation was acquired. RESULT: The optimal matrix formulation is carbopol U10-NoveriteTM7s-glycerine-sorbitol-kaolin-citric acid-aluminum trichloride (1.05.0202.02.00.250.2). CONCLUSION: The matrix has good adhesive property, proper drug release rate, desirable hemocompatibility with the extractions of Pogostemon cablin.