Your browser doesn't support javascript.
A Biblioteca Cochrane foi excluída da BVS por decisão da Wiley de não renovação da licença de uso com a BIREME. Saiba mais.

BVS Odontologia

Informação e Conhecimento para a Saúde

Home > Pesquisa > ()
Imprimir Exportar

Formato de exportação:

Exportar

Email
Adicionar mais destinatários
| |

Testis specific lactate dehydrogenase as target for immunoliposomes.

Dutta, Ranjna C; Goldberg, Erwin.
Am J Reprod Immunol; 60(1): 26-32, 2008 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-18593435

PROBLEM:

Is it possible to deliver therapeutic agents to testis through specific targeting? METHOD OF STUDY Immunoliposomes are designed by incorporating antibodies to lactate dehydrogenase-C4 (LDH-C(4)), which is the product of a testis specific gene. Their targeting and delivering ability is investigated in vitro and in vivo.

RESULTS:

It is observed that LDHC(4)-immunoliposomes are able to discriminate and recognize antigens on spermatozoa and testes both in vitro and in vivo.

CONCLUSION:

Specific targeting through LDH-C(4) appears to be a feasible strategy for delivering therapeutic as well as anti-spermatogenic agents to testis.