Preparation of well-defined poly(ether-ester) macromers: photogelation and biodegradability.
Acta Biomater
; 7(4): 1496-503, 2011 Apr.
Article
em En
| MEDLINE
| ID: mdl-21095246
ABSTRACT
Two series of poly(ether-ester)-based bis-functional macromers terminated with acrylate groups and a well-defined number of ester bonds were synthesized. One series had a chain of 1, 3 or 5 ester bonds at both ends of the central poly(ethylene glycol) block (molecular weight, about 1000), while the other had an alternating structure of oligo(ethylene glycol) each of them linked to two ester bonds, in which 6 or 10 ester bonds were incorporated equally in the macromer molecules and the total molecular weight was adjusted by about 1000. Irradiation of all poly(ether-ester) macromers mixed with camphorquinone resulted in the formation of gels. Gel yield increased and hydrophilic properties of the gels produced decreased with irradiation time. The elastic modulus of the gels decreased with the number of ester bonds. Upon incubation in a PBS solution (pH 8.04), all gels were gradually degraded with time. At 3 weeks of incubation, the degradation ratio increased linearly with the number of ester bonds per unit of molecular weight of the macromers. The order of in vivo degradation rates determined from weight loss was similar to that of the in vitro study. Thus, these poly(ether-ester) macromers may be useful for biodegradable biomaterials or tissue engineering scaffolds.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Poliésteres
/
Géis
/
Luz
Limite:
Animals
Idioma:
En
Revista:
Acta Biomater
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Japão