[Rheological properties of poloxamer 407 aqueous solutions].
Yao Xue Xue Bao
; 46(2): 227-31, 2011 Feb.
Article
em Zh
| MEDLINE
| ID: mdl-21542295
ABSTRACT
Rheological properties of poloxamer 407 (brand named Pluronic F127) were examined by changing shear rate, temperature and the recovery properties of apparent viscosity after heating for several times. The results indicated that poloxamer 407 aqueous solution showed a Newtonian behavior at a low concentration while it might be a pseudoplastic fluid when the concentration reached a certain point. The thixotropy and the sol-gel transition temperature decreased with increasing the concentration (it could be an in situ gel at body temperature when the concentration of poloxamer 407 up to 15.25%). The results that obtained from the theological data would be useful in the application of poloxamer 407 such as in situ gel preparation.
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Base de dados:
MEDLINE
Assunto principal:
Sistemas de Liberação de Medicamentos
/
Poloxâmero
/
Composição de Medicamentos
/
Excipientes
Idioma:
Zh
Revista:
Yao Xue Xue Bao
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
China