Enhanced antiviral activity of acyclovir loaded into nanoparticles.
Methods Enzymol
; 509: 1-19, 2012.
Article
em En
| MEDLINE
| ID: mdl-22568898
ABSTRACT
The activity of antivirals can be enhanced by their incorporation in nanoparticulate delivery systems. Peculiar polymeric nanoparticles, based on a ß-cyclodextrin-poly(4-acryloylmorpholine) monoconjugate (ß-CD-PACM), are proposed as acyclovir carriers. The experimental procedure necessary to obtain the acyclovir-loaded nanoparticles using the solvent displacement preparation method will be described in this chapter. Fluorescent labeled nanoparticles are prepared using the same method for cellular trafficking studies. The biocompatibility assays necessary to obtain safe nanoparticles are reported. Section 4 of this chapter describes the assessment of the antiviral activity of the acyclovir-loaded nanoparticles.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
Resinas Acrílicas
/
Aciclovir
/
Herpesvirus Humano 1
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Beta-Ciclodextrinas
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Nanocápsulas
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Methods Enzymol
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Itália