Antimicrobial hydantoin-containing polyesters.
Macromol Biosci
; 12(8): 1068-76, 2012 Aug.
Article
em En
| MEDLINE
| ID: mdl-22730259
ABSTRACT
A new N-hydantoin-containing biocompatible and enzymatically degradable polyester with antibacterial properties is presented. Different polyesters of dimethyl succinate, 1,4-butanediol, and 3-[N,N-di(ß-hydroxyethyl)aminoethyl]-5,5-dimethylhydantoin in varying molar ratios are prepared via two-step melt polycondensation. The antibacterially active N-halamine form is obtained by subsequent chlorination of the polyesters with sodium hypochlorite. Chemical structures, thermal properties, and spherulitic morphologies of the copolymers are studied adopting FT-IR, NMR, TGA, DSC, WAXD, and POM. The polyesters exhibit antibacterial activity against Escherichia coli. The adopted synthetic approach can be transferred to other polyesters in a straightforward manner.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Poliésteres
/
Succinatos
/
Materiais Biocompatíveis
/
Butileno Glicóis
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Hidantoínas
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Antibacterianos
Idioma:
En
Revista:
Macromol Biosci
Assunto da revista:
BIOQUIMICA
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Alemanha