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In vitro antifungal activity of two tissue conditioners combined with nystatin, miconazole and fluconazole against Candida albicans.

Chopde, Narendra; Pharande, Amol; Khade, Mayur N; Khadtare, Yogesh R; Shah, Sanket S; Apratim, Abhishek.
J Contemp Dent Pract; 13(5): 695-8, 2012 Sep 01.
Artigo em Inglês | MEDLINE | ID: mdl-23250177

AIM:

To determine and compare antifungal activity of two tissue conditioners combined with nystatin, miconazole and fluconazole against Candida albicans. MATERIALS AND

METHODS:

Two tissue conditioners Viscogel and GC Soft combined with nystatin, miconazole and fluconazole were tested against Candida albicans using agar core inhibition diameter assay. One-way analysis of variance followed by Tukey's post-hoc test was used to test the intergroup difference. p-value < 0.05 was considered statistically significant.

RESULTS:

Maximum inhibition was seen in the fluconazole groups followed by miconazole and the least inhibition was seen in case of nystatin group.

CONCLUSION:

Tissue conditioners when mixed with antifungal agents showed satisfactory inhibition of Candida albicans. CLINICAL

SIGNIFICANCE:

Incorporation of antifungal drugs into tissue conditioners shows good inhibition of C. albicans and can be recommended for clinical use.