Soluble, prefibrillar &#945;-synuclein oligomers promote complex I-dependent, Ca2+-induced mitochondrial dysfunction.

Luth, Eric S; Stavrovskaya, Irina G; Bartels, Tim; Kristal, Bruce S; Selkoe, Dennis J

Soluble, prefibrillar α-synuclein oligomers promote complex I-dependent, Ca2+-induced mitochondrial dysfunction.

Luth, Eric S; Stavrovskaya, Irina G; Bartels, Tim; Kristal, Bruce S; Selkoe, Dennis J.

Afiliação

Luth ES; From the Center for Neurologic Diseases, Department of Neurology, and.
Stavrovskaya IG; Department of Neurosurgery, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115.
Bartels T; From the Center for Neurologic Diseases, Department of Neurology, and.
Kristal BS; Department of Neurosurgery, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115.
Selkoe DJ; From the Center for Neurologic Diseases, Department of Neurology, and dselkoe@rics.bwh.harvard.edu.

J Biol Chem ; 289(31): 21490-507, 2014 Aug 01.

Article em En | MEDLINE | ID: mdl-24942732

Assuntos

Biopolímeros/fisiologia; Cálcio/fisiologia; Complexo I de Transporte de Elétrons/metabolismo; Mitocôndrias/fisiologia; alfa-Sinucleína/fisiologia; Animais; Benzotiazóis; Biopolímeros/química; Humanos; Potencial da Membrana Mitocondrial; Camundongos; Tiazóis/metabolismo; alfa-Sinucleína/química

Palavras-chave

Complex I; Electron Transport System (ETS); Mitochondria; Mitochondrial Permeability Transition (MPT); Parkinson Disease; Protein Aggregation; alpha-Synuclein

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Biopolímeros / Cálcio / Complexo I de Transporte de Elétrons / Alfa-Sinucleína / Mitocôndrias Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2014 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google