An uncoupling channel within the c-subunit ring of the F1FO ATP synthase is the mitochondrial permeability transition pore.

Alavian, Kambiz N; Beutner, Gisela; Lazrove, Emma; Sacchetti, Silvio; Park, Han-A; Licznerski, Pawel; Li, Hongmei; Nabili, Panah; Hockensmith, Kathryn; Graham, Morven; Porter, George A; Jonas, Elizabeth A

Alavian, Kambiz N; Beutner, Gisela; Lazrove, Emma; Sacchetti, Silvio; Park, Han-A; Licznerski, Pawel; Li, Hongmei; Nabili, Panah; Hockensmith, Kathryn; Graham, Morven; Porter, George A; Jonas, Elizabeth A.

Afiliação

Alavian KN; Section of Endocrinology, Department of Internal Medicine, Yale University, New Haven, CT 06520-8020;Division of Brain Sciences, Department of Medicine, Imperial College London, London W12 0NN, United Kingdom;
Beutner G; Departments of Pediatrics (Cardiology).
Lazrove E; Section of Endocrinology, Department of Internal Medicine, Yale University, New Haven, CT 06520-8020;
Sacchetti S; Section of Endocrinology, Department of Internal Medicine, Yale University, New Haven, CT 06520-8020;
Park HA; Section of Endocrinology, Department of Internal Medicine, Yale University, New Haven, CT 06520-8020;
Licznerski P; Section of Endocrinology, Department of Internal Medicine, Yale University, New Haven, CT 06520-8020;
Li H; Section of Endocrinology, Department of Internal Medicine, Yale University, New Haven, CT 06520-8020;
Nabili P; Section of Endocrinology, Department of Internal Medicine, Yale University, New Haven, CT 06520-8020;
Hockensmith K; Departments of Pediatrics (Cardiology).
Graham M; Department of Cell Biology, Yale University, New Haven, CT 06520-8002.
Porter GA; Departments of Pediatrics (Cardiology),Internal Medicine (Aab Cardiovascular Research Institute), andPharmacology and Physiology, University of Rochester Medical Center, Rochester, NY 14642; and.
Jonas EA; Section of Endocrinology, Department of Internal Medicine, Yale University, New Haven, CT 06520-8020; elizabeth.jonas@yale.edu.

Proc Natl Acad Sci U S A ; 111(29): 10580-5, 2014 Jul 22.

Article em En | MEDLINE | ID: mdl-24979777

Assuntos

Canais Iônicos/metabolismo; Proteínas de Transporte da Membrana Mitocondrial/metabolismo; Subunidades Proteicas/metabolismo; ATPases Translocadoras de Prótons/metabolismo; Animais; Cálcio/farmacologia; Morte Celular/efeitos dos fármacos; Células HEK293; Humanos; Ativação do Canal Iônico/efeitos dos fármacos; Lipossomos/metabolismo; Mitocôndrias/efeitos dos fármacos; Mitocôndrias/metabolismo; Proteínas de Transporte da Membrana Mitocondrial/química; Membranas Mitocondriais/efeitos dos fármacos; Membranas Mitocondriais/metabolismo; Poro de Transição de Permeabilidade Mitocondrial; Mutação/genética; Conformação Proteica; ATPases Translocadoras de Prótons/química; Ratos; Espécies Reativas de Oxigênio/metabolismo

Palavras-chave

apoptosis; excitotoxicity; ion channel; metabolism; necrosis

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: ATPases Translocadoras de Prótons / Subunidades Proteicas / Proteínas de Transporte da Membrana Mitocondrial / Canais Iônicos Limite: Animals / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2014 Tipo de documento: Article

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