Precious metal carborane polymer nanoparticles: characterisation of micellar formulations and anticancer activity.
Faraday Discuss
; 175: 229-40, 2014.
Article
em En
| MEDLINE
| ID: mdl-25270092
ABSTRACT
We report the encapsulation of highly hydrophobic 16-electron organometallic ruthenium and osmium carborane complexes [Ru/Os(p-cymene)(1,2-dicarba-closo-dodecarborane-1,2-dithiolate)] ( and ) in Pluronic® triblock copolymer P123 core-shell micelles. The spherical nanoparticles and , dispersed in water, were characterized by dynamic light scattering (DLS), cryogenic transmission electron microscopy (cryo-TEM), and synchrotron small-angle X-ray scattering (SAXS; diameter ca. 15 and 19 nm, respectively). Complexes and were highly active towards A2780 human ovarian cancer cells (IC(50) 0.17 and 2.50 µM, respectively) and the encapsulated complexes, as and nanoparticles, were less potent (IC(50) 6.69 µM and 117.5 µM, respectively), but more selective towards cancer cells compared to normal cells.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Compostos Organometálicos
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Neoplasias Ovarianas
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Nanopartículas Metálicas
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Micelas
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Antineoplásicos
Limite:
Female
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Humans
Idioma:
En
Revista:
Faraday Discuss
Assunto da revista:
QUIMICA
Ano de publicação:
2014
Tipo de documento:
Article