Depression of Macrophages Modifies Serum Lipid Profile in Hyperlipidemia.
Bull Exp Biol Med
; 160(5): 617-21, 2016 Mar.
Article
em En
| MEDLINE
| ID: mdl-27021105
ABSTRACT
Suppression of functional activity of macrophages by gadolinium chloride, suppressing the macrophage population and the endocytosis velocity, was studied in vivo. Injection of GdCl3 led to an increase in serum cholesterol concentration. Preliminary injection of GdCl3 to mice with lipidemia 24 h before poloxamer 407 reduced the concentrations of triglycerides and LDL during marked depression of macrophages (in 24 h). Macrophage repopulation (days 5, 7) was associated with development of a trend to an increase of triglyceride and LDL levels. lectron microscopic study of Kupffer cells after injection of poloxamer 407 and its combination with gadoliniun chloride detected the intralysosomal accumulation syndrome in these cells (formation of auto- and heterophagolysosomes). Activity of cathepsin B, characteristic of macrophages, reduced 24 h after injections of GdCl3 and poloxamer 407 alone and restored in response to their combination.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Catepsina B
/
Poloxâmero
/
Gadolínio
/
Hiperlipidemias
/
Macrófagos
Limite:
Animals
Idioma:
En
Revista:
Bull Exp Biol Med
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Federação Russa