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Folic Acid-Functionalized Polythiophene for Targeted Cellular Imaging.

Kim, Hyun-Chul; Kim, Eunjoo; Lee, Se Guen; Lee, Sung Jun; Jeong, Sang Won; Hal, Tae-Lin; Lee, Boram; Lee, Seung Woo.
J Nanosci Nanotechnol; 16(1): 189-95, 2016 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-27398444
Polythiophene containing pendant N-hydroxysuccinimide (NHS) ester groups was reacted with poly(ethylene glycol) (PEG) and oleylamine, which was subsequently modified with folic acid to prepare a targeting fluorescent cellular imaging probe. The amphiphilic character of the folic acid-functionalized polythiophene induced the formation of nanoparticles with an average diameter of 95.3 nm in water. This polymer shows good photostability and low toxicity toward KB cells at a high concentration (100 µg/mL), which meets the crucial requirement for cellular imaging and other biological applications. The folic acid-functionalized polythiophene could be internalized efficiently into KB cells and accumulated in the cytoplasm to yield bright fluorescence, indicating that it is a good candidate material for the fluorescence imaging of living cells.