Synthesis of Leucas Aspera Extract Loaded Gold-PLA-PEG-PLA Amphiphilic Copolymer Nanoconjugates: In Vitro Cytotoxicity and Anti-Inflammatory Activity Studies.
J Nanosci Nanotechnol
; 16(5): 4762-70, 2016 May.
Article
em En
| MEDLINE
| ID: mdl-27483820
ABSTRACT
Gold nanoparticles (GNPs) are synthesized using the medicinal plant Leucas Aspera extract (LAE) and poly lactic acid-co-poly ethylene glycol-co-poly lactic acid (PLA-PEG-PLA) copolymer by water-in-oil (W/O) emulsion method. The proposed method of W/O emulsion technique involves synthesis of GNPs and loading of Leucas Aspera extract on to the PLA-PEG-PLA copolymer matrix simultaneously. The synthesized GNPs are characterized by Fourier transform infra-red (FTIR) spectroscopy, dynamic light scattering (DLS), X-ray diffractometry (XRD) and transmission electron microscopy (TEM). The GNPs-LAE loaded polymer NPs are examined for the in vitro cytotoxicity on South African green monkey's kidney cells. The GNPs-LAE loaded polymer nanoconjugates exhibit maximum up to 95% of cell viability with 100 µg concentration of GNPs in the sample. The GNPs-LAE loaded polymer NPs exhibit better anti-inflammatory activity when compared to the pure LAE.
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Base de dados:
MEDLINE
Assunto principal:
Polietilenoglicóis
/
Sangue
/
Medicamentos de Ervas Chinesas
/
Nanopartículas Metálicas
/
Nanoconjugados
/
Ouro
/
Lactatos
Limite:
Animals
Idioma:
En
Revista:
J Nanosci Nanotechnol
Ano de publicação:
2016
Tipo de documento:
Article