In silico design of anaerobic growth-coupled product formation in Escherichia coli: experimental validation using a simple polyol, glycerol.

Balagurunathan, Balaji; Jain, Vishist Kumar; Tear, Crystal Jing Ying; Lim, Chan Yuen; Zhao, Hua

Balagurunathan, Balaji; Jain, Vishist Kumar; Tear, Crystal Jing Ying; Lim, Chan Yuen; Zhao, Hua.

Afiliação

Balagurunathan B; Bioprocess Engineering Center, Institute of Chemical and Engineering Sciences, Agency for Science, Technology and Research (A*STAR), 1 Pesek Road, Jurong Island, 627833, Singapore.
Jain VK; Industrial Biotechnology Division, Institute of Chemical and Engineering Sciences, Agency for Science, Technology and Research (A*STAR), 1 Pesek Road, Jurong Island, 627833, Singapore.
Tear CJ; Industrial Biotechnology Division, Institute of Chemical and Engineering Sciences, Agency for Science, Technology and Research (A*STAR), 1 Pesek Road, Jurong Island, 627833, Singapore.
Lim CY; Industrial Biotechnology Division, Institute of Chemical and Engineering Sciences, Agency for Science, Technology and Research (A*STAR), 1 Pesek Road, Jurong Island, 627833, Singapore.
Zhao H; Industrial Biotechnology Division, Institute of Chemical and Engineering Sciences, Agency for Science, Technology and Research (A*STAR), 1 Pesek Road, Jurong Island, 627833, Singapore. zhao_hua@ices.a-star.edu.sg.

Bioprocess Biosyst Eng ; 40(3): 361-372, 2017 Mar.

Article em En | MEDLINE | ID: mdl-27796571

Assuntos

Escherichia coli/genética; Escherichia coli/fisiologia; Glicerol/química; Polímeros/química; Saccharomyces cerevisiae/genética; Acetatos/química; Anaerobiose; Simulação por Computador; DNA/química; Escherichia coli/metabolismo; Fermentação; Formiatos/química; Genoma Bacteriano; Genoma Fúngico; Microbiologia Industrial; Engenharia Metabólica/métodos; Plasmídeos/metabolismo; Saccharomyces cerevisiae/metabolismo; Saccharomyces cerevisiae/fisiologia

Palavras-chave

Genome-scale metabolic models; Glycerol; In silico design; Metabolic flux analysis; Reaction knockout

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Polímeros / Saccharomyces cerevisiae / Escherichia coli / Glicerol Tipo de estudo: Prognostic_studies Idioma: En Revista: Bioprocess Biosyst Eng Assunto da revista: BIOTECNOLOGIA / ENGENHARIA BIOMEDICA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Singapura

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