Molecular Dynamics, Recrystallization Behavior, and Water Solubility of the Amorphous Anticancer Agent Bicalutamide and Its Polyvinylpyrrolidone Mixtures.

Szczurek, Justyna; Rams-Baron, Marzena; Knapik-Kowalczuk, Justyna; Antosik, Agata; Szafraniec, Joanna; Jamróz, Witold; Dulski, Mateusz; Jachowicz, Renata; Paluch, Marian

Szczurek, Justyna; Rams-Baron, Marzena; Knapik-Kowalczuk, Justyna; Antosik, Agata; Szafraniec, Joanna; Jamróz, Witold; Dulski, Mateusz; Jachowicz, Renata; Paluch, Marian.

Afiliação

Szczurek J; Institute of Physics, University of Silesia , Uniwersytecka 4, 40-007 Katowice, Poland.
Rams-Baron M; Silesian Center for Education and Interdisciplinary Research , 75 Pulku Piechoty 1A, 41-500 Chorzow, Poland.
Knapik-Kowalczuk J; Institute of Physics, University of Silesia , Uniwersytecka 4, 40-007 Katowice, Poland.
Antosik A; Silesian Center for Education and Interdisciplinary Research , 75 Pulku Piechoty 1A, 41-500 Chorzow, Poland.
Szafraniec J; Institute of Physics, University of Silesia , Uniwersytecka 4, 40-007 Katowice, Poland.
Jamróz W; Silesian Center for Education and Interdisciplinary Research , 75 Pulku Piechoty 1A, 41-500 Chorzow, Poland.
Dulski M; Jagiellonian University , Faculty of Pharmacy, Department of Pharmaceutical Technology and Biopharmaceutics, Medyczna 9, 30-688 Kraków, Poland.
Jachowicz R; Jagiellonian University , Faculty of Pharmacy, Department of Pharmaceutical Technology and Biopharmaceutics, Medyczna 9, 30-688 Kraków, Poland.
Paluch M; Jagiellonian University , Faculty of Pharmacy, Department of Pharmaceutical Technology and Biopharmaceutics, Medyczna 9, 30-688 Kraków, Poland.

Mol Pharm ; 14(4): 1071-1081, 2017 04 03.

Article em En | MEDLINE | ID: mdl-28231007

Assuntos

Antineoplásicos/química; Polímeros/química; Varredura Diferencial de Calorimetria/métodos; Química Farmacêutica/métodos; Cristalização/métodos; Composição de Medicamentos/métodos; Estabilidade de Medicamentos; Excipientes/química; Cinética; Simulação de Dinâmica Molecular; Povidona/química; Solubilidade

Palavras-chave

amorphous bicalutamide; crystallization; glass transition; molecular dynamic; physical stability; polyvinylpyrrolidone

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Polímeros / Antineoplásicos Idioma: En Revista: Mol Pharm Assunto da revista: BIOLOGIA MOLECULAR / FARMACIA / FARMACOLOGIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: Polônia

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google