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All mixed up: defining roles for ß-cell subtypes in mature islets.

Liu, Jennifer S E; Hebrok, Matthias.
Genes Dev; 31(3): 228-240, 2017 02 01.
Artigo em Inglês | MEDLINE | ID: mdl-28270515
Following differentiation during fetal development, ß cells further adapt to their postnatal role through functional maturation. While adult islets are thought to contain functionally mature ß cells, recent analyses of transgenic rodent and human pancreata reveal a number of novel heterogeneity markers in mammalian ß cells. The marked heterogeneity long after maturation raises the prospect that diverse populations harbor distinct roles aside from glucose-stimulated insulin secretion. In this review, we outline our current understanding of the ß-cell maturation process, emphasize recent literature on novel heterogeneity markers, and offer perspectives on reconciling the findings from these two areas.