Noninvasive delivery of oligonucleotide by penetratin-modified polyplexes to inhibit protein expression of intraocular tumor.

Tai, Lingyu; Liu, Chang; Jiang, Kuan; Chen, Xishan; Wei, Gang; Lu, Weiyue; Pan, Weisan

Tai, Lingyu; Liu, Chang; Jiang, Kuan; Chen, Xishan; Wei, Gang; Lu, Weiyue; Pan, Weisan.

Afiliação

Tai L; School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, China; Key Laboratory of Smart Drug Delivery, Ministry of Education, Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai, China.
Liu C; Key Laboratory of Smart Drug Delivery, Ministry of Education, Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai, China.
Jiang K; Key Laboratory of Smart Drug Delivery, Ministry of Education, Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai, China.
Chen X; Key Laboratory of Smart Drug Delivery, Ministry of Education, Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai, China.
Wei G; Key Laboratory of Smart Drug Delivery, Ministry of Education, Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai, China. Electronic address: weigang@shmu.edu.cn.
Lu W; Key Laboratory of Smart Drug Delivery, Ministry of Education, Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai, China.
Pan W; School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, China. Electronic address: pwstfzy@163.com.

Nanomedicine ; 13(6): 2091-2100, 2017 Aug.

Article em En | MEDLINE | ID: mdl-28435135

Assuntos

Proteínas de Transporte/química; Córnea/metabolismo; Sistemas de Liberação de Medicamentos; Inativação Gênica; Glioblastoma/metabolismo; Luciferases/antagonistas & inibidores; Oligonucleotídeos Antissenso/farmacologia; Animais; Sobrevivência Celular/efeitos dos fármacos; Peptídeos Penetradores de Células; Células Cultivadas; Córnea/citologia; Glioblastoma/genética; Glioblastoma/terapia; Luciferases/genética; Masculino; Camundongos; Camundongos Endogâmicos BALB C; Camundongos Nus; Absorção Ocular; Oligonucleotídeos Antissenso/administração & dosagem; Polímeros/química

Palavras-chave

Antisense oligonucleotide; Intraocular drug delivery; Luciferase expression; Penetratin; Polyplex

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas de Transporte / Oligonucleotídeos Antissenso / Sistemas de Liberação de Medicamentos / Glioblastoma / Córnea / Inativação Gênica / Luciferases Limite: Animals Idioma: En Revista: Nanomedicine Assunto da revista: BIOTECNOLOGIA Ano de publicação: 2017 Tipo de documento: Article País de afiliação: China

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