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Opportunities and Challenges in Building a Spatiotemporal Multi-scale Model of the Human Pancreatic ß Cell.

Singla, Jitin; McClary, Kyle M; White, Kate L; Alber, Frank; Sali, Andrej; Stevens, Raymond C.
Cell; 173(1): 11-19, 2018 03 22.
Artigo em Inglês | MEDLINE | ID: mdl-29570991
The construction of a predictive model of an entire eukaryotic cell that describes its dynamic structure from atomic to cellular scales is a grand challenge at the intersection of biology, chemistry, physics, and computer science. Having such a model will open new dimensions in biological research and accelerate healthcare advancements. Developing the necessary experimental and modeling methods presents abundant opportunities for a community effort to realize this goal. Here, we present a vision for creation of a spatiotemporal multi-scale model of the pancreatic ß-cell, a relevant target for understanding and modulating the pathogenesis of diabetes.